Sökning: "purinergic signaling"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden purinergic signaling.

  1. 1. Mechanisms of Shiga toxin-mediated signaling and toxicity

    Författare :Karl Johansson; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EHEC; Shiga toxin; Microvesicles; Purinergic Receptors;

    Sammanfattning : AbstractShiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli (EHEC). EHEC strains cause gastrointestinal infection and release Stx that can gain access to the circulation. Patients may develop hemolytic uremic syndrome with extensive kidney damage. LÄS MER

  3. 2. Roles of the transient receptor potential channels and the intracellular Ca2+ channels in Ca2+ signaling in the beta-cells

    Författare :Amanda Jabin Fågelskiöld; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ca2 signaling;

    Sammanfattning : Previous studies from our group reported that pancreatic β-cells express ryanodine receptors (RyRs) that can mediate Ca2+-induced Ca2+ release (CICR). The full consequences of the activation of RyRs on Ca2+ signaling in these cells, however, remained unclear. LÄS MER

  4. 3. Microvesicle signaling in cardiovascular biology under normal and pathobiological conditions

    Författare :Paulina Bryl-Gorecka; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microvesicles; cardiovascular disease; atherosclerosis; biomarkers; acoustic trapping;

    Sammanfattning : Cardiovascular disease (CVD) is one of the leading causes of death worldwide. Atherosclerosis, a chronic pathology directly related to the circulatory system, develops due to an interplay between several molecular events. Atherosclerotic plaque build-up can lead to a reduction in arterial blood flow and finally, myocardial infarction (MI). LÄS MER

  5. 4. Developmental regulation of smooth muscle contraction in the urinary bladder

    Författare :Mari Ekman; Cellulär biomekanik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; newborn; Rho-kinase; cellular signaling; muscarinic receptors; calcium sensitivity; protein kinase C; non-muscle myosin; myosin light chain phosphatase;

    Sammanfattning : Smooth muscle cells in the urinary bladder are involved in the control of urine filling and emptying. We have used mice to study the contractile regulation of urinary bladder smooth muscle during the fetal period. LÄS MER

  7. 5. Local Purinergic Control of Arteriolar Reactivity in Pancreatic Islets and Renal Glomeruli

    Författare :Xiang Gao; Leif Jansson; Olle Hellberg; Uppsala universitet; []
    Nyckelord :afferent arteriole; islet arteriole; adenosine; A1 receptor; ATP; P2Y receptor; microperfusion; angiotensin II; type 2 diabetes; hypertension; oxidative stress; nitric oxide; tubuloglomerular feedback;

    Sammanfattning : Local control of regional blood flow is exerted mainly through the arterioles. An adequate minute-to-minute regulation of blood perfusion of the kidney and the pancreas is obtained by the modulation of arteriolar reactivity, which will influence the organ function. LÄS MER