Sökning: "preclinical studies"

Visar resultat 1 - 5 av 196 avhandlingar innehållade orden preclinical studies.

1. 1. EGFR and HER2 Targeting for Radionuclide-Based Imaging and Therapy : Preclinical Studies

   Författare :Erika Nordberg; Bengt Glimelius; Jörgen Carlsson; Lars Gedda; Bo Stenerlöw; Vladimir Tolmachev; Peter Bernhardt; Uppsala universitet; []
   Nyckelord :Biomedicine; EGFR; HER2; affibody molecule; tumour targeting; 125I; 111In; Biomedicin;

   Sammanfattning : The optimal way to detect and treat cancer is to target cancer cells exclusively without affecting the surrounding tissue. One promising approach is to use radiolabelled molecules to target receptors that are overexpressed in cancer cells. LÄS MER

3. 2. Radioimmunodiagnosis of Head and Neck Squamous Cell Carcinomas : Preclinical Studies

   Författare :Karl Sandström; Matti Anniko; Marika Nestor; Hans Lundqvist; Göran Laurell; Uppsala universitet; []
   Nyckelord :Head and neck squamos cell carcinoma; radioimmunotargeting; radioimmunodiagnosis; MEDICINE; MEDICIN;

   Sammanfattning : Despite improvements in treatment, the prognosis for patients with advanced head and neck squamous cell carcinomas (HNSCC) has only improved to a minor degree. To raise the success rate and minimize morbidity further developments in diagnostics are highly desired. Radioimmunodiagnosis could offer a more specific and sensitive diagnostic method. LÄS MER

4. 3. Antibody Mediated Radionuclide Targeting of HER-2 for Cancer Diagnostics and Therapy : Preclinical Studies

   Författare :Mikael Persson; Per-Uno Malmström; Vladimir Tolmachev; Jörgen Carlsson; Marion De Jong; Uppsala universitet; []
   Nyckelord :Molecular medicine; Neoplasm Antibodies; Targeted Radiotherapy; Radionuclide Imaging; Molekylärmedicin;

   Sammanfattning : Targeted radionuclide therapy (TRT) holds great promise for the treatment of cancer. In TRT, radioactive nuclides are delivered specifically to tumours by molecules that recognise and bind to structures overexpressed by, or specific to, cancer cells. LÄS MER

5. 4. Radiolabeled HER-2 Binding Affibody Molecules for Tumor Targeting : Preclinical Studies

   Författare :Ann-Charlott Steffen; Jörgen Carlsson; Vladimir Tolmachev; Lars Gedda; Ragnar Hultborn; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; HER-2; affibody; 211At; tumor targeting; targeted radiotherapy; molecular imaging; Biomedicin; Microbiology; Mikrobiologi;

   Sammanfattning : Conventional cancer treatment based on radiotherapy or chemotherapy affects all dividing cells. By directing the therapy specifically to the tumor cells, normal cells can be spared. Tumor targeting molecules carrying a cytotoxic moiety is then an attractive approach. LÄS MER

7. 5. Tumour Targeting Using Radiolabelled EGF Conjugates : Preclinical Studies

   Författare :Åsa Liljegren Sundberg; Jörgen Carlsson; Lars Gedda; Vladimir Tolmachev; Erik Blomquist; Gregory P. Adams; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; targeting; tumour; EGF; radionuclide; gefitinib; Iressa; ZD1839; glioma; therapy; diagnostics; Strålningsvetenskap; Radiation biology; Strålningsbiologi;

   Sammanfattning : Tumour targeted radiotherapy is an appealing approach for treatment of disseminated tumour cells. A targeting agent that specifically binds to a structure on tumour cells is then used to transport therapeutically relevant radionuclides. The epidermal growth factor receptor, EGFR, is overexpressed on tumour cells in several malignancies, e.g. LÄS MER