Sökning: "pharmacophore"
Visar resultat 16 - 16 av 16 avhandlingar innehållade ordet pharmacophore.
16. Electrophysiology-based investigations of G protein-coupled receptor pharmacology
Sammanfattning : G protein-coupled receptors (GPCRs) constitute targets for ~34% of approved drugs. The muscarinic acetylcholine M2 receptor (M2R) activates G protein-coupled receptor inward rectifying potassium (GIRK) channels in the central nervous system and heart. Membrane potential modulates agonist potency at several GPCRs. LÄS MER