Sökning: "pancreatic polypeptide"

Visar resultat 11 - 15 av 37 avhandlingar innehållade orden pancreatic polypeptide.

1. 11. Functional Studies of the Neuropeptide Y System : Receptor-Ligand Interaction and Regulation of Food Intake

   Författare :Helena Åkerberg; Dan Larhammar; Rickard Malmström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropeptide Y; G-protein coupled receptor GPCR ; site-directed mutagenesis; pancreatic polypeptide; food intake; dog; Pharmacology; Farmakologi;

   Sammanfattning : The members of the mammalian neuropeptide Y family, i.e. the peptides neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP), are all involved in regulation of food intake. In human and most other mammals they act via receptors Y1, Y2, Y4 and Y5. LÄS MER

3. 12. Studies of neuropeptides in pancreatic beta cell function with special emphasis on islet amyloid polypeptide (IAPP)

   Författare :Ella Karlsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; alpha cell; amylin; beta cell; chromogranin; growth; IAPP; insulin; islet amyloid polypeptide; leptin; NOD mice; pancreastatin; pancreatic islet; proliferation; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : The presence of protein amyloid in pancreas and its association to diabetes was first described 100 years ago in 1901, but was not identified as Islet Amyloid Polypeptide (IAPP) until 1986. The aim of the present work was to determine the role of the beta cell hormone, IAPP, in normal pancreatic islet physiology and during early disturbances of islet function. LÄS MER

4. 13. Nitric Oxide Synthase in Pancreatic Islets During Trauma and Parenteral Feeding

   Författare :Saleem Qader; Islet cell physiology; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi; Gastroenterologi; Gastro-enterology; Pancreatitis; Ghrelin; TPN; cNOS; iNOS; PACAP; VIP; cAMP; Pancreatic islets; Insulin secretion;

   Sammanfattning : The influence of trauma (acute pancreatitis) or total parenteral nutrition (TPN) on pancreatic islet hormone secretion in relation to islet expression of inducible nitric oxide synthase (iNOS) was investigated. Acute pancreatitis resulted in an impaired glucose-stimulated insulin secretion (GSIS) which was found to be parallelled by a marked expression of iNOS and an exaggerated NO production in the pancreatic islets. LÄS MER

5. 14. In search of early biomarkers in pancreatic ductal adenocarcinoma using multi-omics and bioinformatics

   Författare :Emmy Borgmästars; Malin Sund; Ola Billing; Pär Jonsson; Zelmina Lubovac-Pilav; Oskar Franklin; Stefan Enroth; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Pancreatic cancer; microRNA functional analysis; TPS; miRNomics; metabolomics; proteomics; plasma samples; early detection; risk; survival;

   Sammanfattning : Background: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive malignancy with a 5-year survival of 10 %. Surgery is the only curative treatment. Unfortunately, few patients are eligible for surgery due to late detection. Thus, we need ways to detect the disease at an earlier stage and for that good screening biomarkers could be used. LÄS MER

7. 15. Studies on Islet Amyloid Polypeptide Aggregation : From Model Organism to Molecular Mechanisms

   Författare :Sebastian Schultz; Gunilla Torstensdotter Westermark; Anne Simonsen; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The proper folding of a protein into its defined three--?dimensional structure is one of the many fundamental challenges a cell encounters. A number of tightly controlled pathways have evolved to assist in the proper folding of a protein, but also to aid in the removal of misfolded proteins. LÄS MER