Sökning: "pHPT"

Visar resultat 1 - 5 av 19 avhandlingar innehållade ordet pHPT.

1. 1. Fibroblast growth factor-23 and Klotho in bone/mineral and parathyroid disorders

   Författare :Tijana Krajisnik; Tobias E. Larsson; Kenneth B. Jonsson; Östen Ljunggren; Peyman Björklund; Gunnar Sterner; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcitriol; chronic kidney disease; CKD; chronic renal failure; fibroblast growth factor 23; fibroblast growth factor-23; FGF23; FGF-23; GalNac-T3; GALNT3; GFR; hyperostosis-hyperphosphatemia syndrome; HHS; Klotho; parathyroid hormone; PTH; hyperparathyroidism; pHPT; sHPT; uremic; vitamin D3; Endocrinology; Endokrinologi; Internal Medicine; invärtesmedicin;

   Sammanfattning : Fibroblast growth factor-23 (FGF23) is a novel, bone-produced hormone that regulates renal phosphate (Pi) reabsorption and calcitriol metabolism. Disorders of mineral and bone metabolism, such as autosomal dominant hypophosphatemic rickets (ADHR) and hyperostosis-hyperphosphatemia syndrome (HHS), witness the importance of well-balanced serum levels of FGF23. LÄS MER

3. 2. Cardiovascular disease and adrenergic dysfunction in mild primary hyperparathyroidism

   Författare :Mats Birgander; Internmedicin - epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Primary Hyperparathyroidism; parathyroidectomy; parathyroid hormone; cardiovascular disease; mortality.;

   Sammanfattning : Primary hyperparathyroidism (PHPT) is associated with cardiovascular morbidity and premature death, but the underlying mechanisms are incompletely understood. The aim of this thesis was to investigate cardiovascular parameters and adrenergic function in mild PHPT compared to healthy controls subjects before and after curative parathyroidectomy (PTX). LÄS MER

4. 3. Early parathyroidectomy in mild primary hyperparathyroidism: Effects on heart and bones

   Författare :Erik Almqvist; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; parathyroidectomy; hyperparathyroidism; bone metabolism; testosterone; myocardial hypertrophy; cardiac function; echocardiography; radionuclide angiography; natriuretic peptide; Surgery; orthopaedics; traumatologi; ortopedi; traumatology; Kirurgi;

   Sammanfattning : There is an ongoing controversy regarding how to take care of patients with mild primary hyperparathyroidism (PHPT). Some recommend surgical treatment at diagnosis, others just follow-up as long as there is no evidence of disease progression. LÄS MER

5. 4. Primary hyperparathyroidism : comorbidity and outcome after parathyroid adenomectomy

   Författare :Sophie Norenstedt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Primary hyperparathyroidism (pHPT) is associated with increased mortality in certain malignant tumours. Breast cancer is the most common and a shared aetiology has been suggested. In a register-based nested case-control study, we compared breast cancer in patients with and without a previous operation for pHPT. LÄS MER

7. 5. Primary Hyperparathyroidism - Aspects on skeletal Involvemnt and PTH levels after Surgery

   Författare :Erik Nordenström; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatology; Kirurgi; ortopedi; traumatologi; orthopaedics; Surgery; PTH infusion; PTH levels; Densitometry; Bone density; Primary hyperparathyroidism; Skeletal;

   Sammanfattning : The aim of this thesis was to evaluate risk factors for fractures in patients with primary hyperparathyroidism (pHPT), to study the association between preoperative variables and postoperative changes in bone density and to investigate long-term changes and peripheral PTH sensitivity in patients with elevated PTH levels after surgery. 203 pHPT patients were investigated with regard to clinical and biochemical variables and bone density. LÄS MER