Sökning: "neurite guidance"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden neurite guidance.

  1. 1. Studies on Peripheral Nerve Regeneration: Microdispensing, Neurite Guidance and Galectins

    Författare :Per Gustavsson; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; vävnadskultur; histokemi; cytokemi; Histologi; tissue culture; histochemistry; cytochemistry; Histology; Schwann cells; sciatic nerve; dorsal root ganglia; DRG; neurite guidance; galectins; inkjet; microdispensing; peripheral nervous system; nerve regeneration; Animal physiology; Djurfysiologi; Biotechnology; Bioteknik;

    Sammanfattning : The present thesis describes development of a microdispenser-based technique to create of protein patterns for neurite guidance. The same technique was also developed to allow direct positioning of dissociated cells, including neurons, on cell culture substrates. Finally the role of galectin-3 and 8 during nerve regeneration was investigated. LÄS MER

  3. 2. Brain-derived neurotrophic factor and endocannabinoid functions in gabaergic interneuron development

    Författare :Paul Berghuis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Formation of the cerebral cortex is controlled by tightly regulated processes: the proliferation and survival decisions of neural progenitors, radial and tangential migration of neuronal precursors, axon guidance and dendritic growth underpinning the formation of synapses. Patterning of the neocortex has been extensively studied and significant progress has been made in understanding the principles of cortical neuronal circuit formation. LÄS MER

  4. 3. Trophic factors, neuroprotection and spinal cord repair

    Författare :Johan Widenfalk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :spinal cord injury; GDNF; GFRalpha; neurotrophin; VEGF; olfactory ensheathing glia; weight-drop injury; in situ hybridization;

    Sammanfattning : Background: There is no cure for paralysis. The only drug therapy presently in use, acute high-dose methylprednisolone, has only modest effects on outcome. There is therefore a great need for new therapies. LÄS MER

  5. 4. GDNF and its receptors : a structure-function analysis of the NCAM-GDNF-GFRalpha1 complex and an examination of potential receptor candidates

    Författare :Dan Sjöstrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neurotrophic factors are small, secreted proteins that are important players in the development and maintenance of the nervous system. Their functions span from neuronal survival and migration to neurite outgrowth and axon guidance, and in some cases even programmed cell death. LÄS MER

  7. 5. Tissue engineering of the inner ear

    Författare :Shaden Khalifa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our knowledge of the regenerative ability of the auditory system is still inadequate. Moreover, new treatment techniques for hearing impairment using cochlear implant and tissue engineering, call for further investigations. LÄS MER