Sökning: "levodopa-induced dyskinesia"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden levodopa-induced dyskinesia.

  1. 1. Untangling Cortico-Striatal Circuitry and its Role in Health and Disease - A computational investigation

    Författare :Jovana Belic; Jeanette Hellgren Kotaleski; Arvind Kumar; Abigail Morrison; Arthur Leblois; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cortico-striatal circuits; levodopa-induced dyskinesia; Parkinson’s disease; effective connectivity; cross-frequency coupling; corticostriatal network; network oscillations; GABAergic transmission. basal ganglia; striatum; cortex; fast spiking interneurons; medium spiny neurons; neuronal avalanches;

    Sammanfattning : The basal ganglia (BG) play a critical role in a variety of regular motor and cognitive functions. Many brain diseases, such as Parkinson’s diseases, Huntington’s disease and dyskinesia, are directly related to malfunctions of the BG nuclei. LÄS MER

  3. 2. Levodopa- and Neuroleptic-Induced Dyskinesias : Studies on Pharmacological Modification and Processing of Opioid Neuropeptides

    Författare :Rebecka Klintenberg; Alan Crossman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Opioid peptides; dyskinesia; Parkinson s disease; mass spectrometry; metabolism; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning; biologisk beroendeforskning; Biological Research on Drug Dependence;

    Sammanfattning : Dyskinesias or abnormal involuntary movements are a debilitating complication of long-term levodopa treatment of Parkinson’s disease (PD) that is widely experienced and may compromise the efficacy of the drug therapy. Tardive dyskinesia is another important adverse effect seen with antipsychotic drug treatment. LÄS MER

  4. 3. Circuit-level analyses of cortico-basal ganglia-thalamic networks. Effects of dopamine dysregulation and experience dependent plasticity

    Författare :Nedjeljka Ivica; Integrativ neurofysiologi; []
    Nyckelord :systems neurophysiology; multi-channel recording; motor control; Parkinson s disease; oscillations; dyskinesia; plasticity;

    Sammanfattning : The cortico-basal ganglia-thalamic (CBT) circuit is thought to be involved in control of voluntary and goal-directed movements and action selection. Dopamine is known to play a crucial role in this circuit and regulating its activity. LÄS MER

  5. 4. Functional consequences of dopaminergic degeneration : Clinical and experimental studies using a novel stabilizer of dopaminergic systems

    Författare :Anna Ekesbo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; positron emission tomography; 6-OHDA; MPTP; dyskinesia; dopaminergic degeneration; - -OSU6162; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : Since the introduction of levodopa for the treatment of Parkinson's disease (PD) 30 yearsago, the emergence of motor complications, such as levodopa-induced dyskinesias (LID), hasbeen a major clinical problem in advanced stages of the disease. Clinical and preclinical studieshave revealed a number of functional changes in the dopaminergic system that may be ofimportance for the emergence of LIDs. LÄS MER

  7. 5. The Role of the Cortico-Basal Ganglia-System in Voluntary Movements

    Författare :Martin Tamté; Integrativ neurofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurophysiology; Electrophysiology; Pharmacology; Motor Systems; Voluntary movements; Philosophy; In vivo; Corticostriatal; Parkinson s disease; Dyskinesia; Levodopa; Multiple Electrode Arrays;

    Sammanfattning : Bodies with multiple limbs and joints have endless possibilities to move around in their surrounding space. How the nervous system controls this amount of degrees of freedom in motor execution is a question under vigorous debate. LÄS MER