Sökning: "iron metabolism"

Visar resultat 6 - 10 av 60 avhandlingar innehållade orden iron metabolism.

1. 6. NADH:quinone oxidoreductase: the black box of the respiratory chain

   Författare :Robert Roth; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NADH:quinone oxidoreductase; Complex I; electron transport; membrane protein; ubiquinone; respiratory chain; respiration; metabolism; Metabolism; Biokemi; Biochemistry;

   Sammanfattning : Complex I or NADH:quinone oxidoreductase the largest, most complex and least understood of the five membrane-bound enzyme complexes constituting the mitochondrial respiratory chain. The enzyme is present in all types of organisms, from bacteria to mammals. LÄS MER

3. 7. An Investigation of Peroxidase Activity in Biomimetic and Biological Systems

   Författare :Ekaterina Ryabova; Kemiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; metabolism; Metabolism; enzymologi; Proteiner; enzymology; Proteins; hemoglobin; catalysis; peptide; peroxidase; protoporphyrin IX; Biokemi; Biochemistry;

   Sammanfattning : In order to create a heme environment which permits biomimicry of heme-containing plant peroxidases and investigate the role played by the vinyl side chains of the porphyrin ring on the stability and, possibly, catalytic activity of model compounds, a number of new synthetic microperoxidases -– hemin-6(7)-gly-his methyl ester (HGH) and hemin-6(7)-gly-gly-his methyl ester (HGGH) and hemin-6,7-bis(gly-gly-his methyl ester) (H2GGH) as well as mesohemin-6(7)-gly-gly-his methyl ester (MGGH) and deuterohemin-6(7)-gly-gly-his methyl ester (DGGH) have been prepared by condensation of a peptide residue with the propionic side chains of hemin, mesohemin and deuterohemin, respectively. Reactivity studies towards different organic and inorganic substrates showed that not only five- but also six-coordinate hemin peptide complexes catalyze the oxidation of substrates by H2O2. LÄS MER

4. 8. Oxidative stress and alterations in the mammalian iron metabolism : A study on iron, inflammation, oxidative stress and neurodegeneration

   Författare :Jonas Hälldin; Tiit Land; Paolo Arosio; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : Iron is essential for all living organisms, from bacteria to man for a broad variety of biological functions, including oxygen transport and DNA synthesis. However, iron can also be toxic, due to its involvement in the formation of highly reactive oxygen species through Fenton chemistry. LÄS MER

5. 9. Structural Insights into the Acquisition and Storage of Iron

   Författare :Ulrika Schagerlöf; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Strukturkemi; Molecular biophysics; Molekylär biofysik; Structure chemistry; single particle; ferric reductase; human phagocyte superoxide-generating NADPH oxidase; frataxin; cryo electron microscopy; FRO2; iron homeostasis; iron acquisition;

   Sammanfattning : It is of vital importance to understand the systems for iron metabolism and this thesis contributes to this by providing insights into the structure and function of the acquisition and homeostasis of iron. The two proteins that have been primarily investigated are a ferric reductase from Arabidopsis thaliana called FRO2 and a mitochondrial iron chaperone from Saccharomyces cerevisiae called frataxin. LÄS MER

7. 10. Studies of proteins in heme and iron metabolism

   Författare :Vijole Dzikaite; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Iron; Heme; IRE IRP; Liver; eALAS; HFE;

   Sammanfattning : One aim of the study was to investigate the regulation of the murine erythroid isoform of aminolevulinate synthase (eALAS) protein involved in heme synthesis. Another aim was to characterize the structure of the rat hemochromatosis gene (HFE) gene and its expression in conjunction with other genes involved in the regulation of iron homeostasis during inflammation and iron overload in the rat liver. LÄS MER