Sökning: "interferon-g"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet interferon-g.

  1. 1. Regulation and function of the Mad/Max/Myc network during neuronal and hematopoietic differentiation

    Författare :Anne Hultquist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Myc; Mad1; neuroblastoma; hematopoiesis; phorbol ester; retinoic acid; interferon-g; TGF-b; differentiation.; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : The Mad/Max/Myc transcription factor network takes part in the control of vital cellular functions such as growth, proliferation, differentiation and apoptosis. Dimerization with the protein Max is necessary for the Myc-family of oncoproteins and their antagonists, the Mad-family proteins, to regulate target genes and carry out their intended functions. LÄS MER

  3. 2. Modulation of pain by immune factors : a study on interferon-g and its receptor in nociceptive transmission

    Författare :Kristina S Vikman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cytokines; interferon-gamma; dorsal horn; hypersensitivity; nociceptive transmission; pain; GluR1; AMPA receptor; disinhibition; spontaneous activity; primary cell culture; two-compartment model; spinal cord.;

    Sammanfattning : Immune cytokines have been implicated as important neuromodulators, contributing to neuronal plasticity both in the adult and developing nervous system. In addition, they have been assigned a potential role in the generation of pathological pain, which may occur as a severe symptom following disease states in the nervous system. LÄS MER

  4. 3. Dendritic cell interactions with Gram negative bacteria

    Författare :Mattias Svensson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mycology; virology; Major histocompatibility complex molecules; Dendritic cells; Gram negative bacteria; Antigen processing; Antigen presentation; bacteriology; Microbiology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : The interaction between murine bone marrow-derived dendritic cells (DC) and the Gram negative bacteria Salmonella typhimurium and Escherichia coli have been characterised. These studies showed that DC phagocytosed and processed S. typhimurium and E. LÄS MER

  5. 4. Tumor Necrosis Factor-alpha as a target cytokine in vascular disease

    Författare :Lena Brånén; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; cell replication; Cardiovascular system; Kardiovaskulära systemet; spindle-shaped; epithelioid; smooth muscle cells; periadventitial cuff injury; sTNF-R1; bone marrow transplantation; chimeric fusion protein; atherogenic diet; ApoE; TNF-a; genetically altered mice; en face preparation; atherosclerosis; neointimal hyperplasia;

    Sammanfattning : Inflammation plays an important role in atherosclerosis. One of the most potent pro-inflammatory cytokines is tumor necrosis factor-alpha (TNF-a), a cytokine identified to have a pathogenic role in chronic inflammatory diseases such as rheumatoid arthritis (RA). LÄS MER

  7. 5. Exploring mechanisms regulating the heterogeneity of tumor-associated macrophages

    Författare :Majken Wallerius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Accumulation of macrophages in the tumor microenvironment is associated to poor prognoses in most human cancers. Tumor-associated macrophages (TAMs) represent a heterogeneous and plastic population of cells that contribute to tumor growth, metastatic dissemination, angiogenesis, and immune suppression. LÄS MER