Avancerad sökning

Hittade 5 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Post-Transcriptional Regulation of the Murine Inducible Nitric Oxide Synthase Gene

    Författare :Malin Söderberg; Matti A. Lang; Françoise Raffalli-Mathieu; Eeva Moilanen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; iNOS; inducible nitric oxide synthase; gene regulation; post-transcriptional; mRNA stability; RNA-protein interactions; dexamethasone; murine; heterogeneous nuclear ribonucleoprotein; hnRNPI; hnRNPL; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Sammanfattning : Large amounts of nitric oxide (NO) are produced by the inducible nitric oxide synthase (iNOS) upon inflammatory stimuli. NO is a multifaceted molecule, which may have beneficial effects as an antimicrobial agent in the immune defense, or cytotoxic effects in chronic inflammations, manifested as e.g. arthritis and asthma. LÄS MER

  3. 2. Actin and myosin in transcriptional and post-transcriptional control of gene expression

    Författare :Ales Obrdlik; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Actin plays a key role in basal gene regulation. In the past decade actin has been found to be a component of chromatin remodeling complexes, ribonucleoprotein particles and to associate with all eukaryotic RNA polymerases. LÄS MER

  4. 3. The Multifunctional HnRNP A1 Protein in the Regulation of the Cyp2a5 Gene : Connecting Transcriptional and Posttranscriptional Processes

    Författare :Tina Glisovic; Matti Lang; Francoise Raffalli-Mathieu; Lorenz Poellinger; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; Cyp2a5; DNA-protein interaction; gene regulation; hnRNP A1; nucleocytoplasmic shuttling; RNA-protein interaction; RNA stabilization; posttranscriptional; transcriptional; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Sammanfattning : The mouse xenobiotic-inducible Cyp2a5 gene is both transcriptionally and posttranscriptionally regulated. One of the most potent Cyp2a5 inducers, the hepatotoxin pyrazole, increases the CYP2A5 mRNA half-life. LÄS MER

  5. 4. Regulation of Human Papillomavirus Type 16 Early and Late Gene Expression

    Författare :Haoran Yu; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HPV16; mRNA; Splicing; gene expression;

    Sammanfattning : Human papillomavirus type 16 (HPV16) is a cancer-causing virus that contributes to at least 70% of cervical cancer as well as to other anogenital cancers and head and neck cancer. Understanding HPV16 gene regulation is important to enhance our understanding of HPV16 infections and may contribute to development of antiviral drugs. LÄS MER

  7. 5. Studies of mRNA transport and localization

    Författare :Chandrasekhar Saki Raju; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During mRNA biogenesis, a subset of newly exported mRNA is assembled into larger RNA granules which are transported to subcellular compartments for localized translation. These mechanisms are critical for asymmetric mRNA and protein distribution and have profound impact on cellular physiology. LÄS MER