Sökning: "glypican"

Visar resultat 6 - 10 av 12 avhandlingar innehållade ordet glypican.

  1. 6. Glypican-1: Structural and functional analysis of the N-glycosylated human protein

    Författare :Wael Awad Abdelhady; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteoglycans; glypicans; glypican-1; heparan sulphate; N-glycosylation; exostosin-proteins; X-ray crystallography; crystal dehydration; diffraction anisotropy; Small angle X-ray scattering SAXS9; protein spectroscopy;

    Sammanfattning : Glypicans are multifunctional cell surface heparan sulphate proteoglycans co-regulating numerous signalling pathways, and are thereby involved in the control of cellular division, differentiation, and morphogenesis. The heparan sulphate (HS) chains are responsible for many of those biological functions; nevertheless recent studies suggest functional roles for the glypican core proteins in mediating the signalling of various growth factors. LÄS MER

  3. 7. Tartrate resistant acid phosphatase 5a : a potential regulator of adipocyte cell number and differentiation in white adipose tissue

    Författare :Christina Patlaka; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tartrate-resistant acid phosphatase (TRAP) exists in two isoforms, TRAP 5a which is monomeric and TRAP 5b which is a dimer generated by proteolytic cleavage of TRAP 5a, that exhibit different functions and localizations. TRAP 5a is expressed by adipose tissue macrophages and secreted into the extracellular environment and has been shown to lead to hyperplastic insulin-sensitive obesity when over-expressed in mice. LÄS MER

  4. 8. Studies on the role of Dally-like during Drosophila development

    Författare :Narmada Khare; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Clinical biology; Drosophila; Dally-like; proteoglycans; signal transduction; Klinisk biologi;

    Sammanfattning : A cell is constantly subjected to cues from its surroundings in the form of signalling molecules e.g. Wingless (Wg), Insulin-like growth factor (IGF). As a result, important decisions regarding processes like growth, division, differentiation or migration are made. LÄS MER

  5. 9. Functional and molecular aspects of the glomerular barrier

    Författare :Anna Björnson Granqvist; Göteborgs universitet; []
    Nyckelord :glomerular endothelium; glycocalyx; podocyte; proteoglycan; glycosaminoglycans; nephrotic syndrome;

    Sammanfattning : The kidneys are crucial for maintaining a normal salt-water balance in the body, which is a prerequisite for life. They do that by filtering 180 liters of plasma per day across the highly permselective glomerular barrier and reabsorbing 99 % of the filtrate. LÄS MER

  7. 10. The uterine proteoglycan expression in pregnancy and labor

    Författare :Ann Hjelm Cluff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Labor; dysfunctional labor; heparan sulphate proteoglycans; syndecans; glypicans; perlecans; decorin; connexin 43; gap junctions; myometrial contractions;

    Sammanfattning : Objective: Protracted labor is a common clinical problem causing maternal and fetal complications. It is the leading indication for caesarean sections throughout the world, and emphasizes our need to be able to control labor. LÄS MER