Sökning: "gene activity"

Visar resultat 21 - 25 av 1573 avhandlingar innehållade orden gene activity.

1. 21. Novel methods to study mitochondrial gene expression and homeostasis

   Författare :Magdalena Rzepka; Martin Ott; Christof Osman; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mitochondria; gene expression; metabolism; biokemi; Biochemistry;

   Sammanfattning : Mitochondria are semi-autonomous organelles that harbor one of the main cellular processes – energy conversion. Nutrients available in the environment are taken up by cells and transformed into metabolites that can be used for synthesis of ATP, the energy currency of the cell. LÄS MER

3. 22. Mechanism of conditional repression of human osteocalcin gene activity by glucocorticoids

   Författare :Thomas Meyer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :glucocorticoid receptor; osteocalcin; gene regulation; TATA box element;

   Sammanfattning : Bone is one of the major target sites of steroid hormone action. Steroid hormones like cortisol, vitamin D and estradiol are responsible for principle events associated with bone formation and resorption. LÄS MER

4. 23. Development of nonviral gene delivery and of anti-gene reagents

   Författare :Rongbin Ge; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Although significant progress has been made in the basic science and applications of various non-viral gene delivery systems, the majority of non-viral approaches are still much less efficient than viral vectors, especially for in vivo gene delivery, Therefore, non-viral gene delivery must be developed in order to increase the efficiency of in vivo delivery. Moreover, a novel anti-gene reagent was developed for sequence-specific gene silencing. LÄS MER

5. 24. Towards Gene Therapy of Osteopetrosis

   Författare :Maria Askmyr; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; oc oc mice; osteoclast; hematopoietic stem cells; Hematologi; extracellulära vätskor;

   Sammanfattning : The goal in this thesis is development of gene therapy for malignant infantile osteopetrosis (IMO), a rare but severe genetic bone disease. The concept of osteopetrosis implies dysfunction or lack of osteoclasts, the bone resorbing cells in our body, resulting in failure of normal bone breakdown. LÄS MER

7. 25. Studies of myc gene expression and a novel endoribonuclease activity

   Författare :Anders Wennborg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :c-myc; B-myc; heat-shock; mRNA degradation; endoribonucleases; AUUUAmotifs; RNase E.;

   Sammanfattning : The general aim of this work was to study the regulation of cellular oncogene expression, with emphasis on the c-myc gene, which is de-regulated in several human and animal tumors. The steady-state expression level of c-myc mRNA or protein was analyzed in panels of human Blymphoid cell lines with different growth and transformation properties, and the general observation was a co-variation between high c-myc expression and a more malignant phenotype of the cell lines. LÄS MER