Sökning: "downstream"

Visar resultat 1 - 5 av 1066 avhandlingar innehållade ordet downstream.

  1. 1. Downstream Processing Using Membrane Technology

    Författare :Anna Persson; Avdelningen för kemiteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kemiteknik och kemisk teknologi; Biochemical technology; Chemical technology and engineering; Protein A; Bovine serum albumin; Lactic acid; Electrodialysis; Ultrafiltration; Microfiltration; Downstream processing; Membrane; Biokemisk teknik;

    Sammanfattning : Membrane filtration is a very gentle separation technique and can be used at low temperatures. This makes it suitable for liquids that contain micro-organisms and/or are heat sensitive, which is often the case in liquids processed in the field of biotechnology. LÄS MER

  3. 2. Modeling Antibody Aggregation in Downstream Processing

    Författare :Frida Ojala; Avdelningen för kemiteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Antibody; Aggregation; Downstream processing; Size exclusion chromatography; Reversible reaction model; General rate model;

    Sammanfattning : Antibodies are part of the immune system where their purpose is to recognize and neutralize foreign species such as viruses and bacteria, thus preventing and curing infections. The trend of using antibodies in the treatment of, for example, cancer is increasing. LÄS MER

  4. 3. Tools for digital twins in continuous downstream processing

    Författare :Simon Tallvod; Avdelningen för kemiteknik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Digital twins; Biopharmaceuticals; Downstream processing; Chromatography; Mathematical modeling; Ion exchange; Automation; Sampling; Model calibration; Python;

    Sammanfattning : Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. LÄS MER

  5. 4. Developing integrated downstream processes for next-generation biologics

    Författare :Anton Löfgren; Avdelningen för kemiteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Downstream processing; Preparative chromatography; Optimization; Integration;

    Sammanfattning : Manufacturing of biopharmaceuticals is a costly and time consuming process due to its inherent complexity and variability. The downstream process is the most expensive part and it involves multiple non-trivial steps. Continuous integrated manufacturing is a new concept that is encouraged by authorities. LÄS MER

  7. 5. Mille-feuille Filter : A Non-woven Nano-cellulose Based Virus Removal Filter for Bioprocessing

    Författare :Simon Gustafsson; Albert Mihranyan; Jonas Lindh; Kurt Brorson; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; virus filtration; mille-feuille; downstream; nanocellulose; protein throughput; protein recovery; LRV; MVM; Cladophora; non-woven filter;

    Sammanfattning : Virus removal filters, produced from synthetic surface-modified polymers or regenerated cellulose by phase inversion, are vital to the production of therapeutic proteins such as monoclonal antibodies and plasma proteins. Use of these filters is also one of the most expensive purification steps in the downstream processing of proteins due to high sales price and being limited to a single use. LÄS MER