Sökning: "disease progression"

Visar resultat 11 - 15 av 1144 avhandlingar innehållade orden disease progression.

1. 11. Long Term Outcome and Prediction Models of Cognition, Activities of Daily Living and Nursing Home Placement in Alzheimer’s Disease with Cholinesterase Inhibitor Treatment

   Författare :Carina Wattmo; Klinisk minnesforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; longitudinal studies; nursing home placement; activities of daily living; cognition; Alzheimer s disease; cholinesterase inhibitors; disease progression; predictors; statistical models.;

   Sammanfattning : Background Prospective longitudinal studies in Alzheimer's disease (AD) that include cholinesterase inhibitor (ChEI) treatment in routine clinical settings are scarce. The patients vary in severity of the disease, clinical course, rate of progression and response to treatment. LÄS MER

3. 12. CRISPR/Cas9-based therapies and the role of astrocytes in Alzheimer’s disease and Parkinson’s disease

   Författare :Evangelos Konstantinidis; Martin Ingelsson; Anna Erlandsson; Vilmantas Giedraitis; Magnus Essand; Harald Steiner; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Parkinson s disease; gene editing; CRISPR Cas9; amyloid-beta; astrocytes; neurons; iPSCs; electrophysiology;

   Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative disorders. Whereas the AD brain features plaques of amyloid-beta (Aβ) and neurofibrillary tangles of tau, the PD brain is characterized by Lewy bodies and Lewy neurites containing α-synuclein (αSyn). LÄS MER

4. 13. Urinary Biomarkers and Patient Outcome in Chronic Kidney Disease and Atherosclerotic Heart Disease: The value of IgM-uria and IgG-uria

   Författare :Rafid Tofik; Njurmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteinuria; Albuminuria; urine IgM; urine IgG; glomerulonephritis; chronic kidney disease; atherosclerosis; cardiovascular disease; diabetic kidney disease.;

   Sammanfattning : Risk stratification of patients with chronic kidney disease and atherosclerotic heart disease is crucial. Microalbuminuria (MA) is associated with an increased risk of kidney and cardiovascular (CV) death, especially in patients with diabetes. LÄS MER

5. 14. Early rheumatoid arthritis : biomarkers and hormonal factors in relation to disease progression

   Författare :Antonia Boman; Solbritt Rantapää-Dahlqvist; Ewa Berglin; Gerd-Marie Alenius; Mikael Brink; Heidi Kokkonen; Inger Gjertsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Early rheumatoid arthritis; biomarker; ACPA; RANKL; disease activity; radiological destruction; cardiovascular events; hormonal factors; reumatologi; rheumatology;

   Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, affecting approximately 0.5 to 1% of the adult population. Although the aetiology is not fully known, a complex interaction between genetic, environmental and stochastic factors is thought to trigger the pathogenic mechanisms. LÄS MER

7. 15. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling

   Författare :Nina Gennebäck; Stellan Mörner; Anders Waldenström; Urban Hellman; Ali J Marian; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac hypertrophy; HCM; gene expression; OPLS-DA; multivariate dataanalysis; cardiomyocytes; exosomes; microvesicles; Medicine; medicin;

   Sammanfattning : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. LÄS MER