Sökning: "Stellan Mörner"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Stellan Mörner.

1. 1. Hypertrophic cardiomyopathy in Northern Sweden : with special emphasis on molecular genetics

   Författare :Stellan Mörner; Åke Hjalmarson; Umeå universitet; []
   Nyckelord :Hypertrophic cardiomyopathy; genetics; autonomic nervous system; familial amyloid polyneuropathy; echocardiography; Epidemiology; epidemiologi;

   Sammanfattning : Hypertrophic cardiomyopathy (HCM) is a heterogeneous, often familial disease, characterized by cardiac hypertrophy, predominantly affecting the interventricular septum. To date, no study has systematically analysed the genetic and phenotypic aspects of the disease in a Swedish population. LÄS MER

3. 2. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling

   Författare :Nina Gennebäck; Stellan Mörner; Anders Waldenström; Urban Hellman; Ali J Marian; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac hypertrophy; HCM; gene expression; OPLS-DA; multivariate dataanalysis; cardiomyocytes; exosomes; microvesicles; Medicine; medicin;

   Sammanfattning : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. LÄS MER

4. 3. About hyaluronan in the hypertrophic heart : studies on coordinated regulation of extracellular matrix signalling

   Författare :Urban Hellman; Anders Waldenström; Stellan Mörner; Anna Engström-Laurent; Lena Jonasson; Umeå universitet; []
   Nyckelord :hyaluronan; hyaluronan synthases; gene expression; extracellular matrix; cardiac hypertrophy; rat wistar; male ; cardiomyocytes; growth factors; fibroblasts; microvesicles; exosomes; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. LÄS MER

5. 4. Left atrial function in health and disease

   Författare :Mark Henein; Per Lindqvist; Stellan Mörner; Reidar Winter; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Left atrium; Doppler echocardiography; atrial interaction; atrial pressure;

   Sammanfattning : The Objectives of this thesis are:1) To study possible atrial interaction in patients with right and left ventricular outflow tract obstruction due to significant pulmonary (PS) and aortic valve stenosis (AS), respectively.2) To assess left atrial (LA) intrinsic myocardial function and its relationship to indirect measures of left ventricular (LV) filling pressures in patients with paroxysmal atrial fibrillation (PAF). LÄS MER

7. 5. Insights into the effect of myocardial revascularisation on electrical and mechanical cardiac function

   Författare :Ihab Ramzy Guirguis; Michael Y Henein; Stellan Mörner; Reidar Winter; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; myocardial infarction; natriuretic peptides; echocardiography; ventricular function; atrial function; surgical revascularisation; speckle tracking echocardiography; Cardiology; kardiologi;

   Sammanfattning : Background: Acute coronary syndrome is known for its effect on cardiac function and can lead to impaired segmental and even global myocardial function. Evidence exists that myocardial revascularisation whether pharmacological, interventional or surgical results in improvement of systolic and diastolic left ventricular (LV) function, particularly that of the long axis which represents the sub-endocardial function, known as the most sensitive layer to ischaemia. LÄS MER