Sökning: "Vilmantas Giedraitis"

Hittade 3 avhandlingar innehållade orden Vilmantas Giedraitis.

  1. 1. Candidate gene analyses and genome-wide screens in multiple sclerosis

    Författare :Vilmantas Giedraitis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Specific disease causing mutations have been identified for many disorders. Most of these disorders are of Mendelian origin and there have been very few successful attempts in the genetic dissection of complex traits. LÄS MER

  3. 2. CRISPR/Cas9-based therapies and the role of astrocytes in Alzheimer’s disease and Parkinson’s disease

    Författare :Evangelos Konstantinidis; Martin Ingelsson; Anna Erlandsson; Vilmantas Giedraitis; Magnus Essand; Harald Steiner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Parkinson s disease; gene editing; CRISPR Cas9; amyloid-beta; astrocytes; neurons; iPSCs; electrophysiology;

    Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative disorders. Whereas the AD brain features plaques of amyloid-beta (Aβ) and neurofibrillary tangles of tau, the PD brain is characterized by Lewy bodies and Lewy neurites containing α-synuclein (αSyn). LÄS MER

  4. 3. Characterization of the novel “Uppsala mutation” causing a familial form of early onset Alzheimer’s disease

    Författare :María Pagnon de la Vega; Martin Ingelsson; Dag Sehlin; Vilmantas Giedraitis; Gunnar Gouras; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; neurodegeneration; amyloid precursor protein; APP processing; amyloid beta; transgenic mouse model;

    Sammanfattning : The Alzheimer’s disease (AD) brain displays extracellular plaques of amyloid-β (Aβ), neurofibrillary tangles of tau and neuronal loss. The 40-42 amino acid Aβ peptide is formed from the amyloid precursor protein (APP) by β-secretase and γ-secretase, while α-secretase prevents Aβ generation. LÄS MER