Sökning: "disease progression"

Visar resultat 16 - 20 av 1144 avhandlingar innehållade orden disease progression.

  1. 16. Computational Modeling of Cancer Progression

    Författare :Hossein Shahrabi Farahani; Jens Lagergren; Niko Beerenwinkel; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer progression; Bayesian networks; microRNA editing; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Sammanfattning : Cancer is a multi-stage process resulting from accumulation of genetic mutations. Data obtained from assaying a tumor only contains the set of mutations in the tumor and lacks information about their temporal order. Learning the chronological order of the genetic mutations is an important step towards understanding the disease. LÄS MER

  3. 17. Prognosis and progression in chronic kidney disease

    Författare :Marie Evans; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Analgesics; Chronic Kidney Disease; Epidemiology; Dialysis; Glomerular Filtration Rate; Lead Metal Exposure; Survival;

    Sammanfattning : Chronic kidney disease (CKD) is a life threatening condition with high risk of pre-term death and need for dialysis. The population prevalence of CKD has been estimated to 10-13% for both Europe and the USA. LÄS MER

  4. 18. Characterization of proteins involved in disease progression in Alzheimer disease

    Författare :Michael Axenhus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer disease (AD) is a neurodegenerative disease and severe neuronal loss is already taking place at the time of diagnosis. AD affects nearly 50 million people worldwide and the incidence is expected to rise significantly in the coming decades, making the disease a high priority healthcare concern. LÄS MER

  5. 19. Ex‘PLA’ining the progression of pathological proteins in Alzheimer’s and Parkinson’s diseases : see(d)ing is believing

    Författare :Anish Behere; Joakim Bergström; Sara Ekmark-Lewén; Martin Ingelsson; Stina Syvänen; Hilal Lashuel; Uppsala universitet; []
    Nyckelord :Alpha synuclein; Tau; Proteoforms; Phosphorylation; Oligomers; Proximity Ligation Assay; sensitive detection of pathology; Alzheimer s disease; Parkinson s disease; pS129; pS202 pT205; pT231; PFFs;

    Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common forms of neurodegenerative disorders affecting approximately 50 million people worldwide. The underlying neuropathological processes leading to AD and PD share many similarities, i.e. aberrant protein aggregation of tau and alpha-synuclein (αSyn) in the brain. LÄS MER

  7. 20. HIV-1 evolution, disease progression and molecular epidemiology of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals in Guinea-Bissau

    Författare :Joakim Esbjörnsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; HIV-2; Guinea-Bissau; subtype; disease progression; evolution; coreceptor tropism; CXCR4; gp120; V1-V3; CD4%; CD8%; soluble immune markers;

    Sammanfattning : The two genetically related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 infected individuals. LÄS MER