Sökning: "direct repeats"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden direct repeats.

  1. 1. Structural Studies of Flexible Biomolecules and a DNA-binding Protein

    Författare :Tariq Massad; Pål Stenmark; Cheryl Arrowsmith; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Maximum entropy; motilin; DNA-binding proteins; Karplus equation; disaccaride; direct repeats; Structural biology; Strukturbiologi; Biophysics; biofysik;

    Sammanfattning : The knowledge of the three-dimensional structures of proteins and polypeptides is essential to understand their functions. The work shown in this thesis has two objectives. LÄS MER

  3. 2. Genomic studies of expanded trinucleotide repeats : focus on neuropsychiatric disorders

    Författare :Kerstin Lindblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :affective disorder; CTG18.1; DNA; ERDA1; expanded trinucleotide repeats; gene isolation; mutation; Parkinson s disease; repeat expansion detection; repeat instability; spinocerebellar ataxia;

    Sammanfattning : In a number of neurological and neuropsychiatric disorders, a worsening of the disease phenotype from one generation to the next has been linked to expanded trinucleotide repeat sequences that increase in size upon transmission. The clinical phenomenon of an earlier age of onset or a more severe phenotype in later generations of a family has been termed anticipation. LÄS MER

  4. 3. Repetitive DNA in search of a function - a study of telomeric and centromeric sequences in Chironomus

    Författare :Casimiro Castillejo-Lopez; Udo Häckers grupp Utvecklingsbiologi i invertebrater; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chironomus; CENP-B box; mobile elements; reverse transcriptase; gene conversion; satellite; repetitive DNA; Telomere; centromere; Genetics; cytogenetics; Genetik; cytogenetik;

    Sammanfattning : Repetitive DNA is quantitatively the main component of telomeres and centromeres, structures responsible for maintenance of the eukaryotic chromosome. The telomere is the specialized nucleoprotein complex that terminates linear chromosomes. LÄS MER

  5. 4. Thyroid hormones and their receptors in transcriptional regulation

    Författare :Monika Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thyroid hormone receptor; regulatory response element; palindrome; directrepeat; everted repeat; DNA hinding domain; P75gag-v-erbA; differentiation; nuclearlocalization; repression.;

    Sammanfattning : The thyroid hormone receptors (TRs) are encoded by two genes, alpha and ß, and belong to a family of hormone activated nuclear receptors. This family includes the receptors for retinoids and vitamin D3 as well as the receptors for steroid hormones. LÄS MER

  7. 5. Transcriptional regulation by the thyroid hormone receptor and its viral counterpart : the P75gag-V-erbA oncoprotein

    Författare :Gunilla Wahlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Transcriptional regulation; thyroid hormone; TR; P75gag-v-erbA; repression; Avian erythroblastosis virus; response elements; RXR; retinoids.;

    Sammanfattning : Thyroid hormone binds to specific DNA binding receptors (TRs) in the cell nucleus and thus regulates transcription during development and in some pathological disorders. The gene of the viral TR homologue, v-erbA, is one of two oncogenes encoded in the genome of avian erythroblastosis virus (AEV). LÄS MER