Sökning: "dioxin"

Visar resultat 16 - 20 av 85 avhandlingar innehållade ordet dioxin.

1. 16. Adseverin – An Immune-Specific Target of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

   Författare :Camilla Svensson; Lars Wärngård; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; 2; 3; 7; 8-Tetrachlorodibenzo-p-dioxin; TCDD; adseverin; aryl hydrocarbon receptor; immunotoxicity; thymus; cytoskeleton; Toxikologi; Toxicology; Toxikologi; Toxicology; toxikologi;

   Sammanfattning : The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces thymus atrophy and immunosuppression in all animal species examined and these effects constitute a potential risk to humans. TCDD can via binding to the intracellular aryl hydrocarbon receptor (AhR), modulate transcription of a number of genes and the aim of this thesis has been to identify such genes, which may explain the mechanisms behind TCDD-mediated immunotoxicity. LÄS MER

3. 17. Trace analysis of dioxins and dioxin-like PCBs using comprehensive two-dimensional gas chromatography with electron capture detection

   Författare :Conny Danielsson; Peter Haglund; Karin Wiberg; Jean-Marie Dimandja; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Comprehensive two-dimensional gas chromatography; GC × GC; µECD; PCDDs; PCDFs; dioxins; dioxin-like PCBs; Pressurized liquid extraction; PLE; PLE-C; food; feed; fly ash; soil; Environmental chemistry; Miljökemi;

   Sammanfattning : Polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), two groups of struc-turally related chlorinated aromatic hydrocarbons, generally referred to as “dioxins” are of great concern due to their extreme toxicity and presence in all compartments of the environment. Since they occur at very low levels, their analysis is complex and challenging, and there is a need for cost-efficient, reliable and rapid analytical alternatives to the expensive methods in-volving use of gas chromatography high-resolution mass spectrometry (GC-HRMS). LÄS MER

4. 18. Regulation of dioxin receptor function by procarcinogenic food-derived heterocyclic amines and indolocarbazoles

   Författare :Marika I Kleman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :heterocyclic aromatic amine; indolocarbazole; dioxin receptor; CYPlA;

   Sammanfattning : Cooking of protein-rich food generates procarcinogenic heterocyclic aromatic amines(HCA) in amounts that range in the part per billion levels. The capacity of the two most prevalent HCA, PhIP and MelQx, to induce genetic alterations in vivo was determined using a short-term liver carcinogenesis model (RH-model) in rat. LÄS MER

5. 19. Regulation of dioxin receptor function by the Hsp90 chaperone complex

   Författare :Arunas Kazlauskas; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : In mammals the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors includes the dioxin receptor which is a ligand-dependent transcription factor which mediates biological effects of environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin). In the absence of ligand, the dioxin receptor is associated with the molecular chaperone Hsp90 and two Hsp90-interacting proteins, the co-chaperone p23 and an immunophilin-like protein XAP2. LÄS MER

7. 20. Mechanism of conditional regulation of the bHLH/PAS dioxin receptor

   Författare :Jacqueline McGuire; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The intracellular dioxin receptor is a bHLH/PAS protein which mediates signal transduction by dioxin and upon heterodimerisation with the bHLH/PAS partner factor Arnt, functions as a ligand-activated transcription factor by binding to specific xenobiotic response elements in promoters of target genes. Although the physiological function of the dioxin receptor and the nature of a possible physiological ligand are presently not known, targeted disruption of the mouse dioxin receptor gene has indicated that the receptor may play an important role in hepatic development. LÄS MER