Sökning: "Jacqueline McGuire"

Hittade 1 avhandling innehållade orden Jacqueline McGuire.

1. 1. Mechanism of conditional regulation of the bHLH/PAS dioxin receptor

   Författare :Jacqueline McGuire; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The intracellular dioxin receptor is a bHLH/PAS protein which mediates signal transduction by dioxin and upon heterodimerisation with the bHLH/PAS partner factor Arnt, functions as a ligand-activated transcription factor by binding to specific xenobiotic response elements in promoters of target genes. Although the physiological function of the dioxin receptor and the nature of a possible physiological ligand are presently not known, targeted disruption of the mouse dioxin receptor gene has indicated that the receptor may play an important role in hepatic development. LÄS MER