Sökning: "depression-like behavior"

Hittade 4 avhandlingar innehållade orden depression-like behavior.

  1. 1. Galanin receptor subtypes in rodent models of mood disorders

    Författare :Tara Wardi-Le Maitre; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :5-HT1A receptor; galanin; galanin receptor 2 overexpressing mice; locus coeruleus; dorsal raphe; depression-like behavior; forced swim test;

    Sammanfattning : Major depressive disorder (MDD) is a serious mental illness, with a complex etiology. It is a multifactorial disorder caused by a combination of genetic, environmental and epigenetic factors. Exposure to stressful life events seems to be a common, contributing cause of morbidity. LÄS MER

  3. 2. Effects of excess glucocorticoids on neural cell fate : long lasting consequences of adverse prenatal factors

    Författare :Mirko Conti; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The developing nervous system is particularly vulnerable to high level of glucocorticoids (GCs). Excess GCs is often associated with decreased birth weight in relation to gestational age, and to increased risk of psychiatric disorders, like depression, later in life. LÄS MER

  4. 3. Mediators of synaptic activity in anxiety- and depression-related behaviors

    Författare :Carly Kiselycznyk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Depression and anxiety are leading causes of years lost to disability, despite antidepressants being among the most commonly prescribed medications. Most currently prescribed antidepressants were found serendipitously rather than from an understanding of the biological mechanisms underlying depression. LÄS MER

  5. 4. A Glial Role in the Action of Electroconvulsive Therapy

    Författare :Malin Wennström; Enheten för psykiatrisk neuromodulering (PNU); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psykiatri; klinisk psykologi; psykosomatik; psychosomatics; clinical psychology; Psychiatry; Hippocampus; Depression; Gliogenesis; Electroconvulsive seizures;

    Sammanfattning : The aim of the current thesis was to investigate glial responses to electroconvulsive seizures (ECS), an animal model of the fast-acting antidepressant treatment electroconvulsive therapy (ECT). Depression, a common and devastating disorder, has in recent years been associated with volumetric changes in prefrontal cortex, hippocampus and amygdala, brain regions known to be implicated in emotional behavior. LÄS MER