Sökning: "damage accumulation"

Visar resultat 1 - 5 av 205 avhandlingar innehållade orden damage accumulation.

  1. 1. Radiation response in human cells : DNA damage formation, repair and signaling

    Författare :Ann-Sofie Gustafsson; Bo Stenerlöw; Andrzej Wojcik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionizing radiation; heat-labile sites; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Ionizing radiation induces a range of different DNA lesions. In terms of mutation frequency and mammalian cell survival, the most critical of these lesions is the DNA double-strand break (DSB). DSB left unrepaired or mis-repaired may result in chromosomal aberrations that can lead to permanent genetic changes or cell death. LÄS MER

  3. 2. Damage accumulation and stiffness degradation in composite laminates

    Författare :Roberts Joffe; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Polymeric Composite Materials; Polymera konstruktionsmaterial;

    Sammanfattning : In the presented thesis analytical modeling of elastic properties degradation and modeling of damage evolution in composite laminates is performed. Transverse cracking initiation on a fiber/matrix level is briefly studied by testing model composites and cross-ply laminates. LÄS MER

  4. 3. Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae

    Författare :Sandra Malmgren Hill; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aging; protein damage; quality control; metacaspase; aggregates; segregation; vacuole;

    Sammanfattning : The process of aging is defined as a time-dependent decline in cellular functionality, and aging is thought to have evolved as organisms were optimized for reproduction, at the cost of an imperfect repair and maintenance system. As a consequence, different kinds of dysfunctional components and damage accumulate over time. LÄS MER

  5. 4. Development of a Morphology-based Analysis Framework for Asphalt Pavements

    Författare :Ibrahim Onifade; Björn Birgisson; Nicole Kringos; Denis Jelagin; William G. Buttlar; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Morphology; damage; X-ray computed tomography; top-down cracking; fracture; Morfologi; skador; röntgendatortomografi; ’top-down’sprickbildning; fraktur; Byggvetenskap; Civil and Architectural Engineering; Teknisk materialvetenskap; Materials Science and Engineering;

    Sammanfattning : The morphology of asphalt mixtures plays a vital role in their properties and behaviour. The work in this thesis is aimed at developing a fundamental understanding of the effect of the asphalt morphology on the strength properties and deformation mechanisms for development of morphology-based analysis framework for long-term response prediction. LÄS MER

  7. 5. Rolling Contact Fatigue of Railway Rails with Emphasis on Crack Initiation

    Författare :Jonas Ringsberg; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; variable amplitude; crack closure; rolling contact fatigue; crack propagation; railway rails; damage accumulation; critical plane approach; crack initiation; plasticity; multiaxial fatigue;

    Sammanfattning : Increased traffic density and the heavier axle loads of modern trains have led to severe problems with rolling contact fatigue (RCF) which cause initiation of surface cracks in railheads. In this thesis, a specific type of surface crack, the head check, is studied numerically with emphasis on fatigue crack initiation. LÄS MER