Sökning: "cyclosporin A"
Visar resultat 1 - 5 av 31 avhandlingar innehållade orden cyclosporin A.
1. The effects of cyclosporin A on bone turnover and repair
Sammanfattning : The effects of cyclosporin A on bone metabolism are unclear and controversial. The aims of this thesis were to study the effects of cyclosporin A on bone turnover and on different repair processes such as fracture healing, osteoinduction and osteoconduction. LÄS MER
2. Regulation of T lymphocyte activity : studies using monoclonal antibodies and cyclosporin A
Sammanfattning : .... LÄS MER
3. Cyclosporin A-induced gingival overgrowth in renal transplant patients : a clinical, histological and experimental study
Sammanfattning : Cyclosporine A (CsA) is widely used as an effective immunosuppressive agent to prevent rejection of organ transplants, as well as in the treatment of patients with various autoimmune diseases. The clinical use of CsA, however, is associated with adverse side effects, including nephrotoxicity, hepatotoxicity, hypertension, and neurotoxicity as well as gingival overgrowth. LÄS MER
4. Calcium-induced mitochondrial permeability transition in CNS-derived mitochondria - Pharmacological aspects of specificity and toxicity in neuroprotection
Sammanfattning : Mitochondria are the main site for energy conversion in the cell. Under certain circumstances, such as excess calcium retention or production of reactive oxygen species, a pore forms at contact sites between the outer and the normally impermeable inner mitochondrial membrane. LÄS MER
5. Effects of immunosuppressive drugs on human adipose tissue metabolism
Sammanfattning : The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action on the immune system, these agents have serious long-term metabolic side-effects, including dyslipidemia and new onset diabetes mellitus after transplantation. LÄS MER