Sökning: "conformational gating"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden conformational gating.

  1. 1. Conformational Changes during Potassium-Channel Gating

    Författare :Jakob Renhorn; Fredrik Elinder; David Engblom; Stephan Pless; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ion-channel; electrophysiology; neuron; Jonkanal; neurologi; elektrofysiologi; neuron; aktionspotential;

    Sammanfattning : Voltage-gated ion channels have a paramount importance in many physiological processes such as cell-to-cell communication, action potential-propagation, and cell motility. Voltage-gated ion channels are characterized by their ability to sense membrane voltage and to greatly change channel activity in response to small changes in the voltage. LÄS MER

  3. 2. Elucidating the Gating Mechanism of Cys-Loop Receptors

    Författare :Özge Yoluk; Erik Lindahl; Philip Biggin; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ion channel; gating; simulation; molecular dynamics; receptor; cys-loop; modelling; Teoretisk kemi och biologi; Theoretical Chemistry and Biology; Biological Physics; Biologisk fysik;

    Sammanfattning : Cys-loop receptors are membrane proteins that are key players for the fast synaptic neurotransmission. Their ion transport initiates new nerve signals after activation by small agonist molecules, but this function is also highly sensitive to allosteric modulation by a number of compounds such as anesthetics, alcohol or anti-parasitic agents. LÄS MER

  4. 3. Porphyrin-Based Donor-Bridge-Acceptor Systems: Intrinsic Excited State Deactivation and Intramolecular Energy/Electron Transfer Reactions

    Författare :Joakim Andreasson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; spectroscopy; superexchange; mediation; energy transfer; porphyrins; conformational gating; conformational distortions; electron transfer;

    Sammanfattning : Intramolecular energy and electron transfer reactions have been studied between porphyrin donor and acceptor moieties. The porphyrin units are covalently linked together by one of three different bridging chromophores to constitute the series of D-B-A systems. LÄS MER

  5. 4. Voltage sensor activation and modulation in ion channels

    Författare :Christine S Schwaiger; Lindahl Erik; Paolo Carloni; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage sensor; VSD; gating; Kv1.2-2.1; Shaker; F233; hydrophobic barrier;

    Sammanfattning : Voltage-gated ion channels play fundamental roles in neural excitability, they are for instance responsible for every single heart beat in our bodies, and dysfunctional channels cause disease that can be even lethal. Understanding how the voltage sensor of these channels function is critical for drug design of compounds targeting neuronal excitability. LÄS MER

  7. 5. The molecular basis for substrate recognition and gating in sugar transporters

    Författare :Sarah McComas; David Drew; Philip Biggin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; membrane transport; sugar transporter; simulations; lipids; antimalarial drugs; biokemi; Biochemistry;

    Sammanfattning : Sugar is a vital sustenance for most forms of life. For a cell to take up sugar, specialized transport proteins embedded into the membrane bilayer known as sugar porters, are required. LÄS MER