Sökning: "circulating fatty acids"

Visar resultat 1 - 5 av 45 avhandlingar innehållade orden circulating fatty acids.

  1. 1. Dietary Fatty Acids and Inflammation : Observational and Interventional Studies

    Författare :Helena Bjermo; Ulf Risérus; Tommy Cederholm; Parveen Yaqoob; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dietary fat; Fatty acids; Serum fatty acid composition; Linoleic acid; Stearoyl coenzymeA desaturase; SCD-1; Inflammation; C-reactive protein; Oxidative stress; Lipid peroxidation; Isoprostanes; Prostaglandins; Obesity; Epidemiology; Dietary intervention; Metabolic syndrome; Nutrition; Näringslära; Epidemiology; Epidemiologi; Public health science; Folkhälsovetenskap; Immunology; Immunologi; Diabetology; Diabetologi; Cardiology; Kardiologi; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Dietary fat quality influences the risk of type 2 diabetes and cardiovascular disease. A low-grade inflammation is suggested to contribute to the disease development, often accompanied by obesity. Whereas n-3 polyunsaturated fatty acids (PUFA) have been considered anti-inflammatory, n-6 PUFA have been proposed to act pro-inflammatory. LÄS MER

  3. 2. Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans

    Författare :Mariam Rodríguez-Lee; Göteborgs universitet; []
    Nyckelord :proteoglycans; glycosaminoglycans; fatty acids; smooth muscle cells; hepatocytes; LDL binding; remnant clearance; insulin resistance; type 2 diabetes;

    Sammanfattning : Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins (LDL) in the intima by chondroitin sulfate (CS)-rich proteoglycans (PG). LÄS MER

  4. 3. Role of Fatty Acid Composition in Non-Alcoholic Fatty Liver Disease: a Dietary Perspective : Results from Interventional and Observational Studies

    Författare :Michael Fridén; Ulf Risérus; Fredrik Rosqvist; Helen Lindqvist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fatty acids; Diet; Biomarkers; NAFLD; Liver fat; Fibrosis; Cirrhosis; HCC; Nutrition; Nutrition;

    Sammanfattning : The overall aim of this doctoral thesis was to investigate the role of circulating, liver and dietary fatty acids in non-alcoholic fatty liver disease (NAFLD). For circulating and liver fatty acids, special emphasis was given to fatty acids reflecting diet. LÄS MER

  5. 4. Free fatty acids and insulin hypersecretion studied in human islets

    Författare :Jing Cen; Peter Bergsten; Miriam Cnop; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; free fatty acids; palmitate; human islets; EndoC-βH1 cells; metformin; sorcin; insulin secretion; mitochondrial respiration; ER stress; human transcriptome array; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Free fatty acid (FFA) levels are increased in many obese subjects. High FFA levels stimulate the pancreatic beta-cells but have negative long-term effects. In obese children with high FFA levels circulating insulin concentration is high early in life but decline with age precipitating the development of type 2 diabetes mellitus (T2DM). LÄS MER

  7. 5. Cytokines and lipids in pregnancy – effects on developmental programming and placental nutrient transfer

    Författare :Susanne Lager; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue; amino acids; cytokines; developmental programming; free fatty acids; insulin resistance; interleukin-6; lipoprotein lipase; nutrient transport; placenta; toll-like receptor 4;

    Sammanfattning : Metabolic disturbances, in particular those associated with nutritional challenges, that take place during development, both in utero and early postnatal life, have long-lasting health consequences on an individual. The most pronounced evidence of these challenges is a deviation in birth weight. LÄS MER