Sökning: "Genetic disposition"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden Genetic disposition.

  1. 1. Genetic influence on enantiomeric drug disposition Focus on venlafaxine and citalopram

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Maria Kingbäck; Linköpings universitet.; Linköpings universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : A molecule that is not identical to its mirror image is said to be chiral. A racemic mixture, or a racemate, is one that has equal amounts of S- and R-enantiomers of a chiral molecule. Two examples of frequently prescribed racemic drugs are the antidepressants venlafaxine (VEN) and citalopram (CIT). LÄS MER

  2. 2. On the hypersensitivity syndrome induced by the selective serotonin reuptake inhibiting antidepressant Zimeldine : A clinical and experimental study

    Detta är en avhandling från Linköping : Linköpings universitet

    Författare :Bengt-O Bengtsson; Linköpings universitet.; Linköpings universitet.; [1992]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Zimeldine; Norzimeldine; Hypersensitivity syndrome; Serotonin reuptake inhibition; Genetic disposition; Lymphocyte transformation test; Experimental allergic neuritis; Immunopharmacology; MEDICINE; MEDICIN;

    Sammanfattning : Zimeldine, the first selective neuronal serotonin (5-H1) reuptake inhibitor to be registered as an antidepressant was withdrawn from common use due to an acute flu-like adverse syndrome comprising fever, myalgia and/or arthralgia and signs of disturbed liver function. A few of these patients also developed a peripheral neuropathy, in the most serious form a Guillain-Barré syndrome (GBS). LÄS MER

  3. 3. Genetic determinants of breast cancer risk

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics

    Författare :Jingmei Li; Karolinska Institutet.; Karolinska Institutet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Neoplasms;

    Sammanfattning : The main purpose of this thesis was to identify genetic risk factors using both hypothesis-based and hypothesis-free approaches. In an attempt to identify common disease susceptibility alleles for breast cancer, we started off with a hypothesis-free approach, and performed a combined analysis of three genome-wide association studies (GWAS), involving 2,702 women of European ancestry with invasive breast cancer and 5,726 controls. LÄS MER

  4. 4. Genetics of androgen disposition : Implications for doping tests

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Laboratory Medicine

    Författare :Jenny Jakobsson Schulze; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Anabolic androgenic steroids (AAS) are derivatives of testosterone. Doping with AAS is a severe challenge to the vision, moral and ethics in sports and has also become an increasing problem in society. Testosterone abuse is conventionally assessed by the urinary testosterone glucuronide/ epitestosterone glucuronide (T/E) ratio, levels above 4. LÄS MER

  5. 5. In vitro and in silico prediction of drug-drug interactions with transport proteins

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Gustav Ahlin; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC transporter; OCT1; Organic cation transporter 1; SLC22A1; OATP1B1; SLCO1B1; Organic anion transporting peptide 1B1; Drug transport; Active transport; Genetic polymorphism; Cell lines; Gene expression; Multivariate data analysis; OPLS; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; Pharmaceutics; galenisk farmaci; biofarmaci; Biopharmaceutics;

    Sammanfattning : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. LÄS MER