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Visar resultat 1 - 5 av 46 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Development and Application of Human Chromosome 22 Genomic Microarray : Chromosome 22-Associated Disorders Analyzed by Array-Based Comparative Genomic Hybridization

   Författare :Magdalena Benetkiewicz; Jan Dumanski; Niklas Dahl; Frank Speleman; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; DNA copy number changes; chromosome 22; genomic microarray; array-CGH; schwannoma; neurofibromatosis type 2; ovarian carcinoma; breast cancer; Wilms tumor; Genetik; Genetics; Genetik;

   Sammanfattning : The array-based form of comparative genomic hybridization (array-CGH) is a new methodology that has shown to be of significant importance. This thesis focuses on the development of array-CGH with the aim to define candidate regions/genes on chromosome 22 in a wide spectrum of cancer-related conditions. LÄS MER

3. 2. Molecular studies of genetic changes in myxoid and round cell liposarcoma

   Författare :Sofia Järnum; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; onkologi; cancer; Medicine human and vertebrates ; Medicin människa och djur ; oncology; Cytology; autocrine loop; RDA; persephin; RET; LEPREL1; translocation; fusion gene; liposarcoma; TLS; CHOP;

   Sammanfattning : Chromosomal translocations commonly result in the production of fusion genes and the fusion genes are often tumor-type specific. In myxoid and round cell liposarcomas (MLS/RCLS), almost 95% of the cases carry a t(12;16)(q13;p11). In the remaining 5% of the MLS/RCLS tumors, another translocation and fusion gene can be found, i.e. LÄS MER

4. 3. Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms

   Författare :Marta Persson; Göteborgs universitet; []
   Nyckelord :cancer genetics; fusion oncogenes; chromosome translocation; MYB; NFIB; CRTC1; MAML2; salivary gland; breast; adenoid cystic carcinoma; mucoepidermoid carcinoma; hidradenoma;

   Sammanfattning : Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown that recurrent chromosome translocations often result in fusion oncogenes. LÄS MER

5. 4. Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma and other cartilage tumors

   Författare :Helene Sjögren; Göteborgs universitet; []
   Nyckelord :Extraskeletal myxoid chondrosarcoma; chondroblastoma; chondrosarcoma; spectral karyotyping SKY ; chromosome translocation; fusion oncogene; cDNA microarray; TEC; EWS; TAF2N; TCF12;

   Sammanfattning : .... LÄS MER

7. 5. Studies of PLAG1 and HMGIC fusion oncogenes in human tumors

   Författare :Anna-Karin Ström; Göteborgs universitet; []
   Nyckelord :Pleomorphic adenoma; carcinoma ex pleomorphic adenoma; lipoblastoma; PLAG1; HMGIC; chromosome translocation; promoter swapping; fusion oncogene; gene amplification;

   Sammanfattning : .... LÄS MER