Sökning: "biomarker"

Visar resultat 31 - 35 av 777 avhandlingar innehållade ordet biomarker.

1. 31. Urinary Clara cell protein and alpha 1-microglobulin – biomarkers of changes in kidney and airway function

   Författare :Lena Andersson; Göteborgs universitet; []
   Nyckelord :biomarker; Clara cell 16 kDa protein CC16 ; alpha 1-microglobulin A1M ; ambient air pollution; renal function; pyelonephritis; children;

   Sammanfattning : Validated biomarkers are useful tools for screening large populations. The benefit of screening may be improved risk assessment or early indications of adverse effects before detection or onset of symptoms. LÄS MER

3. 32. Bioimaging for analysis of protein expression in cells and tissues using affinity reagents

   Författare :Emma Lundberg; Torbjörn Gräslund; Mathias Uhlén; Rainer Pepperkok; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Affibody; antibody; biomarker; cell line; cell microarray; colorectal cancer; confocal microscopy; HER2; immunohistochemistry; immunofluorescence; light microscopy; protein expression; protein localization; SATB2; tissue microarray; Bioengineering; Bioteknik; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : The detection and analysis of biomolecules, such as proteins, are of great interest since these molecules are fundamental for life and our health. Due to the complexity of biological processes, there is a great advantage of studying proteins in their natural context, for example by using bioimaging. LÄS MER

4. 33. Exposure and effects of naturally produced hydroxylated polybrominated diphenyl ethers in fish : Implications for Baltic Sea wildlife

   Författare :Johan Gustafsson; Lillemor Asplund; Pim E.G. Leonards; Marja H. Lamoree; Robert Letcher; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ecotoxicology; Metabolomics; OH-PBDE; Algae; Cyanobacteria; Natural products; Thiamine; Health; Biomarker; Seasonal variation; Perch; Zebrafish; Flame retardant; Mixture; 6-OH-BDE47; Energy metabolism; Endocrine disruption; Neurotoxicity; OXPHOS; Environmental Chemistry; miljökemi;

   Sammanfattning : The aim of this thesis was to investigate if naturally produced hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are causing negative health effects for Baltic Sea wildlife. In the laboratory, OH-PBDEs have shown to be potent disrupters of energy metabolism as well as endocrine disruptors and neurotoxins. LÄS MER

5. 34. Mass Spectrometric Applications for Diagnosing Metabolic and Endocrine Diseases

   Författare :Mark M. Kushnir; Jonas Bergquist; Alan L Rockwood; David Herold; Uppsala universitet; []
   Nyckelord :Analytical chemistry; biomarker; liquid chromatography; tandem mass spectrometry; LC-MS MS; sample preparation; isomers; steroid hormones; congenital adrenal hyperplasia; polycystic ovary syndrome; Analytisk kemi;

   Sammanfattning : Disease-specific compounds (biomarkers) are analyzed in clinical laboratories to assist with diagnosing diseases. This thesis describes development and validation of liquid chromatography tandem mass spectrometry (LC-MS/MS) based tests for diagnosing a diverse group of endocrine and metabolic diseases. LÄS MER

7. 35. Epitope mapping of antibodies towards human protein targets

   Författare :Barbara Hjelm; Mathias Uhlén; Larry Gold; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antibody; antibody validation; biomarker; epitope mapping; peptide array; proteomics; RBM3; staphylococcal surface display;

   Sammanfattning : This thesis, based on five research papers, presents results from development and evaluation ofmethods for identifying the interaction site of antibodies on their antigens and the functional investigation of these in different assays. As antibodies have proven to be invaluable tools in diagnostics, therapy and basic research, the demand of characterizing these binding molecules has increased. LÄS MER