Sökning: "biomarker"

Visar resultat 41 - 45 av 777 avhandlingar innehållade ordet biomarker.

  1. 41. Computational discovery of DNA methylation patterns as biomarkers of ageing, cancer, and mental disorders : Algorithms and Tools

    Författare :Behrooz Torabi Moghadam; Jan Komorowski; Manfred Grabherr; Jaak Vilo; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA methylation; machine learning; biomarker; cancer; ageing; classification;

    Sammanfattning : Epigenetics refers to the mitotically heritable modifications in gene expression without a change in the genetic code. A combination of molecular, chemical and environmental factors constituting the epigenome is involved, together with the genome, in setting up the unique functionality of each cell type. LÄS MER

  3. 42. Proximity Ligation and Barcoding Assays : Tools for analysis of proteins and protein complexes

    Författare :Di Wu; Masood Kamali-Moghaddam; Ulf Landegren; Ola Söderberg; Jörg Hoheisel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; proximity barcoding assay; sensitive; in situ; multiplex; profiling; amyloid-beta; MARK; tau; CSF; biomarker; protein complexes; Alzheimer’s disease; amyotrophic lateral sclerosis; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of proteins, such as by measuring their concentrations, characterizing their modifications, and detecting their interactions, provides insights in how biological systems work physiologically or pathologically at the molecular level. LÄS MER

  4. 43. Systemic effects after ionizing radiation exposure: Genome-wide transcriptional analysis of mouse normal tissues exposed to (211)At, (131)I, or 4 MV photon beam

    Författare :Britta Langen; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microarray; radiogenomics; systemic effects; biomarker; radionuclide therapy; radionuclide therapy;

    Sammanfattning : The radionuclides 131I and 211At are used or proposed for a variety of cancer treatments. Both radiohalogens exhibit considerable uptake in the thyroid gland and–to a lower degree–in various other tissues if they are unbound or released from a cancer-targeting agent. LÄS MER

  5. 44. Adrenomedullin in sepsis

    Författare :Oscar Lundberg; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; biomarker; adrenomedullin; endothelin-1; high-sensitivity troponin t; intensive care unit; emergency department; septic shock;

    Sammanfattning : AbstractBackgroundSepsis is a syndrome difficult to diagnose and stratify. The epidemiology of sepsis and consistency of criteria fulfillment with diagnosis coding in Swedish intensive care units (ICU) are largely unknown. Biomarkers can be of help to understand pathophysiology, identify clusters within sepsis and to individualize treatment. LÄS MER

  7. 45. Interpretation of variation in omics data : Applications in proteomics for sustainable agriculture

    Författare :Jakob Willforss; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; agriculture; proteomics; omics; biomarker; normalization; batch effect; visualization; software;

    Sammanfattning : Biomarkers are used in molecular biology to predict characteristics of interest and are applied in agriculture to accelerate the breeding of target traits. Proteomics has emerged as a promising technology for improved markers by providing a closer view to the phenotype than conventional genome-based approaches. LÄS MER