Sökning: "albumin"

Visar resultat 1 - 5 av 350 avhandlingar innehållade ordet albumin.

  1. 1. An albumin-binding domain as a scaffold for bispecific affinity proteins

    Författare :Johan Nilvebrant; Sophia Hober; Andrew Bradbury; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; albumin-binding domain; bispecific; albumin; affinity protein; phage display; staphylococcal display; orthogonal affinity purification; TNF-alpha; ErbB2; ErbB3; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Sammanfattning : Protein engineering and in vitro selection systems are powerful methods to generate binding proteins. In nature, antibodies are the primary affinity proteins and their usefulness has led to a widespread use both in basic and applied research. LÄS MER

  3. 2. NMR Studies of Bacterial Albumin-Binding Modules

    Författare :Maria U Johansson; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fysikalisk kemi; Biotechnology; Bioteknik; Proteins; enzymology; Proteiner; enzymologi; Physical chemistry; three-helix bundle; protein structure; protein PAB; protein-protein interactions; protein G; protein dynamics; NMR; module shuffling; GA module; evolution; albumin-binding; bacterial surface proteins;

    Sammanfattning : Peptostreptococcus magnus and group C/G streptococci are Gram-positive cocci that are part of the normal flora and reside in more or less the same locations in the host. Protein G of group C/G streptococci was originally described as binding IgGFc of several species and later shown to also bind human serum albumin and albumins from various animal species. LÄS MER

  4. 3. Evasion and Attack: Structural Studies of a Bacterial Albumin-binding Protein and of a Cephalosporin Biosynthetic Enzyme

    Författare :Sara Lejon; Janos Hajdu; Karin Valegård; Martin Noble; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; human serum albumin; GA module; albumin-binding; Finegoldia magna; deacetylcephalosporin C acetyltransferase; cephalosporin C; antibiotic; beta-lactam; biosynthesis; Acremonium chrysogenum; X-ray crystallography; Structural biology; Strukturbiologi;

    Sammanfattning : This thesis describes the crystal structures of two proteins in the context of combatting bacterial infections. The GA module is a bacterial albumin-binding domain from a surface protein expressed by pathogenic strains of the human commensal bacterium Finegoldia magna. LÄS MER

  5. 4. Transvascular exchange and organ perfusion with reference to colloid and hypertonic solutions, and to endotoxaemia

    Författare :Staffan Holbeck; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; mannitol; microdialysis; intestine; hypertonic saline; gut; hydroxyethyl starch; gelatin; endotoxin; fluid therapy; dextran; albumin; capillary filtration coefficient; intensivvård; Anestesiologi; urea; Anaesthesiology; intensive care; SIRS; reflection coefficient;

    Sammanfattning : Changes in vascular permeability can immensely change plasma volume and affect the degree of oedema in the body. In diseases with an increased vascular permeability, adequate fluid therapy is of considerable importance to prevent hypovolaemia. LÄS MER

  7. 5. The Microcirculation in Trauma and Sepsis

    Författare :Peter Bansch; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microcirculation; prostacyclin; plasma vilume; trauma; sepsis; sidestream darkfield imaging; albumin; volume expansion; transcapillary escape rate; glycocalyx; charge;

    Sammanfattning : The microcirculation plays a vital part for fluid-, gas- and solute-exchange, and changes in permeability during trauma or sepsis, that are in part necessary for the natural healing process, may also cause hypovolemia and edema formation, leading to disturbances in microvascular exchange. This thesis discusses changes is microvascular flow, permeability and plasma volume (PV) loss after experimental or surgical trauma and experimental sepsis. LÄS MER