Sökning: "acetylcholinesterase inhibitors"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden acetylcholinesterase inhibitors.

  1. 1. Towards Mosquitocides for Prevention of Vector-Borne Infectious Diseases : discovery and Development of Acetylcholinesterase 1 Inhibitors

    Författare :Sofie Knutsson; Anna Linusson; Fredrik Almqvist; Andreas Larsson; Ulf Nilsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mosquito; vector-borne diseases; vector control; insecticide; acetylcholinesterase; medicinal chemistry; high-throughput screening; organic synthesis; homology modeling; structure activity relationship; structure selectivity relationship; datorlingvistik; computational linguistics; organisk kemi; Organic Chemistry;

    Sammanfattning : Diseases such as malaria and dengue impose great economic burdens and are a serious threat to public health, with young children being among the worst affected. These diseases are transmitted by mosquitoes, also called disease vectors, which are able to transmit both parasitic and viral infections. LÄS MER

  3. 2. Selective inhibition of acetylcholinesterase 1 from disease-transmitting mosquitoes : design and development of new insecticides for vector control

    Författare :Cecilia Engdahl; Anna Linusson; Fredrik Ekström; Zoran Radić; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; non-covalent inhibitor; vector control; insecticide; mosquito; vector-borne disease; high throughput screening; rational design; biokemi; Biochemistry; datorlingvistik; computational linguistics;

    Sammanfattning : Acetylcholinesterase (AChE) is an essential enzyme with an evolutionary conserved function: to terminate nerve signaling by rapid hydrolysis of the neurotransmitter acetylcholine. AChE is an important target for insecticides. LÄS MER

  4. 3. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase

    Författare :Lotta Berg; Anna Linusson; Fredrik Ekström; Joel L. Sussman; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; drug discovery; density functional theory; hydrogen bond; nerve-agent antidote; non-covalent interaction; protein-ligand complex; structure-based design; thermodynamics; X-ray crystallography; datorlingvistik; computational linguistics;

    Sammanfattning : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. LÄS MER

  5. 4. Validation of brief cognitive tests in mild cognitive impairment, Alzheimer's disease and dementia with Lewy bodies

    Författare :Sebastian Palmqvist; Klinisk minnesforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cognitive tests; neuropsychology; Alzheimer’s disease; dementia with Lewy bodies; mild cognitive impairment; treatment evaluation; acetylcholinesterase inhibitors; differential diagnosis; longitudinal studies; dementia; cerebrospinal fluid; forecasting;

    Sammanfattning : Background It is estimated that 34 million people suffer from dementia, costing society US$422 billion each year. Alzheimer’s disease (AD) is the most common dementia and the global prevalence is predicted to increase to over 100 million people by the year 2050, with the greatest increase in developing countries. LÄS MER

  7. 5. Molecular changes of acetylcholinesterase and butyrylcholinesterase in Alzheimer patients during the natural couse of the disease and treatment with cholinesterase inhibitors : insight into neurochemical mechanisms affecting the progression of the disease

    Författare :Taher Darreh-Shori; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer disease; acetylcholinesterase; butyrylcholinesterase; cholinesterase inhibitors;

    Sammanfattning : Deficits in central cholinergic neurotransmission in the brain correlate with cognitive impairment in Alzheimer disease (AD) patients. This fact has resulted in the introduction of cholinesterase inhibitors (ChEls) e.g. LÄS MER