Sökning: "TrxR1"

Visar resultat 21 - 25 av 29 avhandlingar innehållade ordet TrxR1.

  1. 21. Gallbladder and pancreatic disease in patients with primary sclerosing cholangitis

    Författare :Karouk Said; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cholecystitis; gallbladder; ejection fraction; magnetic resonance imaging; pancreatic duct; chronic pancreatitis; thioredoxin; Immunohistochemical staining;

    Sammanfattning : The aims of this study were to assess the occurrence of gallbladder abnormalities and dysfunction, to evaluate clinically useful biomarkers for premalignancy and malignancy in gallbladder epithelium and to assess presence of pancreatic duct changes and early pancreatic abnormalities in patients with primary sclerosing cholangitis (PSC). In paper I and III we investigated presence of gallbladder abnormalities in 286 patients with PSC treated at Karolinska University Hospital, Huddinge, between 1970 and 2005. LÄS MER

  3. 22. Cytotoxic mechanisms of selenium in cancer

    Författare :Eric Olm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Selenium is an essential trace element with a diverse number of functions in the body as part of multiple selenoproteins. Acknowledged for its cancer preventive properties in clinical trials, selenium has in recent years also evolved as a potential chemotherapeutic agent. LÄS MER

  4. 23. Exploring thioredoxin reductase as an anticancer drug target

    Författare :Stefanie Prast-Nielsen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mammalian thioredoxin reductase (TrxR; EC 1.8.1.9) is a homodimeric NADPH-dependent selenium-containing flavoenzyme with disulfide oxidoreductase activity. LÄS MER

  5. 24. Selenium compounds as a novel class of experimental cancer chemotherapeutics

    Författare :Arun Kumar Selvam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Selenium is an essential micronutrient for humans, it has a narrow margin between antioxidant and pro-oxidant effects. Redox-active selenium compounds have the potency to increase ROS levels in cancer cells, providing a plausible window for therapeutic intervention. LÄS MER

  7. 25. Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling

    Författare :Markus Dagnell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein tyrosine phosphatases (PTPs) are reversibly oxidized upon activation of platelet-derived growth factor receptor beta (PDGFβR). Dys-regulation of the PDGFβR signaling pathway is associated with several diseases, including cancers and cardiovascular disease, and is thus a known driver of disease progression. LÄS MER