Sökning: "TrxR1"

Visar resultat 11 - 15 av 29 avhandlingar innehållade ordet TrxR1.

1. 11. Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53

   Författare :Meiqiongzi Zhang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows evasion of cell death and rapid tumor progression. LÄS MER

3. 12. Cancer vaccine strategies and studies of human thioredoxin reductase splice variants

   Författare :Pascal Dammeyer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cancer involves abnormal, uncontrolled proliferation of cells, and evasion from the immune system. Immune evasion can be caused by defects in one or more of the components of the major histocompatibility complex class I antigen machinery, e.g. the beta2-microglobulin (beta2m) molecule. LÄS MER

4. 13. Functional characterization of cytosolic and mitochondrial thioredoxin reductases

   Författare :Ivan Nalvarte; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Thioredoxin; thioredoxin reductase; reactive oxygen species; mitochondria; differentiation; redox signaling; ubiquinone; cytochrome c; selenium; selenoprotein.;

   Sammanfattning : Mammalian thioredoxin reductases (TrxRs) are homodimeric selenoproteins belonging to the nucleotide oxidoreductase family. They contain a C-terminal penultimate selenocysteine residue, which is kept reduced by the N-terminal redox active site, CVNVGC, of the adjacent subunit. LÄS MER

5. 14. Shedding light on the STAT3 small molecule inhibitor field

   Författare :Sander Busker; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as progression. However, there are still no STAT3 inhibitors applied in the clinic. LÄS MER

7. 15. Molecular mechanisms of growth suppression by pharmacologically activated p53

   Författare :Elisabeth Hedström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The tumor suppressor p53 is a transcription factor that is crucial for protecting cells from cancer development. The importance of p53 tumor suppression function is highlighted by the fact that the p53 pathway is inactivated in most, if not all cancers. LÄS MER