Sökning: "Triplex"

Visar resultat 1 - 5 av 19 avhandlingar innehållade ordet Triplex.

  1. 1. Development of benzoquinoquinoxaline derivatives as triplex-specific probes : Recognition of DNA structures at repeats sequences

    Författare :Helen Bergquist; Rula Zain; Keith Fox; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Triplex; H-DNA; BQQ; BQQ-OP; BQQ-Bodipy; triplet repeat; DNA; non-B-DNA; pkd1; frataxin; Friedreich s ataxia; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Repeat sequences are associated with several human diseases, such as Friedreich’s ataxia, polycystic kidney disease and cancer. These sequences can form non-B-DNA structures, including triplex (H-DNA) DNA, and are associated with genomic instability and altered gene expression. LÄS MER

  3. 2. Fixation of Functionalized DNA Nanostructures

    Författare :Erik Lundberg; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; triplex recognition; dna; self-assembly; gel electrophoresis; nanotechnology; cross-linking; spectroscopy; fixation; fret; click chemistry;

    Sammanfattning : This thesis features results from two different studies on a fully addressable non-repetitive network on the nanometre scale, assembled by synthetic DNA molecules. A bio-inspired molecular approach, based on principles of self-assembly, has brought about a paradigm shift in nanoscience, from a top-down to a bottom-up perspective. LÄS MER

  4. 3. Structural Adaptation of DNA to Small Ligands and Recombination Proteins

    Författare :Hye-Kyung Kim; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; triplex DNA; groove binders; intercalators; SANS; DNA; optical spectroscopy; recombination proteins;

    Sammanfattning : In order to contribute to the understanding of mechanisms of recognition in nucleic acid systems, the interaction of DNA with a variety of ligands, representing different cases of adaptation of the double-helix structure, was studied using flow linear dichroism (LD), circular dichroism (CD), fluorescence and absorption spectroscopic techniques. A chiral hydrophobic metal complex, [Ru(dpphen)3]2+ was examined, since this had been reported to be the most efficient molecule to discriminate DNA handedness. LÄS MER

  5. 4. Bottom-up Fabrication of Functional DNA Nanostructures

    Författare :Erik Lundberg; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; click chemistry; gel electrophoresis; self-assembly; cross-linking; lipid membrane; fixation; linear dichroism; nanotechnology; spectroscopy; fret; dna; triplex recognition;

    Sammanfattning : This thesis demonstrates bottom-up fabrication of a fully addressable non-repetitive network on the nanometer scale, assembled by synthetic DNA molecules. Each side constitutes a unique sequence of 10 bases, i.e. 3. LÄS MER

  7. 5. Dissertatio philosophica triplex, quam bono cum Deo consensu amplissima facultatis philosophica, præside ... Martino Brunnero ... Publico examini submittit Johannes Colvmbvs s. r. m. alumnus. in audit. Gustav. maj, die [tomrum] Ianuar. anno 1667

    Författare :Martin Brunnerus; Johannes Columbus; Martin Brunnerus; Uppsala universitet; []
    Nyckelord :HUMANIORA; HUMANITIES;

    Sammanfattning : .... LÄS MER