Sökning: "TME"

Visar resultat 1 - 5 av 37 avhandlingar innehållade ordet TME.

1. 1. Rectal cancer surgery : Defunctioning stoma, anastomotic leakage and postoperative monitoring

   Författare :Peter Matthiessen; Olof Hallböök; Rune Sjödahl; Lars Påhlman; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anterior resection of the rectum; total mesorectal excision; TME; anastomotic leakage; defunctioning stoma; risk factors; intraoperative adverse events; population based study; postoperative monitoring; CT-scan microdialysis; cytokines; Surgery; Kirurgi;

   Sammanfattning : The understanding of the mesorectal spread in rectal cancer has lead to wide acceptance of total mesorectal excision (TME) as the surgical technique of choice for carcinoma in the lower and mid rectum. While oncological results and survival have improved with TME-surgery, morbidity and mortality remain important issues. LÄS MER

3. 2. The identification and functional evaluation of novel cancer-associated fibroblast subtypes and matrisome proteins in pancreatic cancer

   Författare :Joshua Cumming; Daniel Öhlund; Cedric Patthey; Jenny Persson; Claus Jørgensen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer-associated fibroblast CAF ; Single-cell RNA sequencing scRNAseq ; Pancreatic ductal adenocarcinoma PDAC ; Tumor microenvironment TME ; Extracellular matrix ECM ; Organoid-based co-culture model; Drug-screen; Oncology; onkologi;

   Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an extensive desmoplastic stroma. The stroma is the site of intricate communication between malignant cells and their surrounding environment. LÄS MER

4. 3. Immunologic Markers in the Tumor Microenvironment of Classical Hodgkin Lymphoma

   Författare :Alex R. Gholiha; Gunilla Enblad; Rose-Marie Amini; Peter Hollander; Gustaf Hedström; Arjan Diepstra; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor microenvironment; immunohistochemistry; immune checkpoints; Plasma cells; IL-6 cytokine; Proteomics; CD47.;

   Sammanfattning : In classical Hodgkin lymphoma (cHL), cytokine regulation and cellular composition of the tumor microenvironment (TME) is crucial for tumor cell survival. In paper I, we examined the presence of CD138+ plasma cells and IgG4+ plasma cells in diagnostic cHL biopsies with immunohistochemistry (IHC). LÄS MER

5. 4. Rectal cancer : staging, radiotherapy and surgery

   Författare :Anna Martling; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Rectal cancer; surgery; radiotherapy; staging; prognosis;

   Sammanfattning : In Sweden, about 1800 patients are annually diagnosed with adenocarcinoma of the rectum. Surgery remains the major primary treatment. Adjuvant radiotherapy and total mesorectal excision (TME) are two major achievements in rectal cancer treatment during the last two decades. LÄS MER

7. 5. Art of tumor immunity : extricating hypoxia-driven immunosuppression in the solid tumor microenvironment

   Författare :Apple Tay; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The fate of tumors, from initiation to in situ carcinoma and ultimately metastasis, is intricately tied to the balance between the immune system’s effector cytotoxic and tolerogenic immunosuppressive responses, collectively known as tumor immunity. However, this balance is disrupted by hypoxia, a common characteristic of solid tumors, which drives immunosuppression and contributes to the heterogeneity of the solid tumor microenvironment (TME). LÄS MER