Sökning: "Sex-stratified"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet Sex-stratified.

  1. 1. Human leukocyte antigen in sickness and in health : Ankylosing spondylitis and HLA in Sweden

    Författare :Jessika Nordin; Kerstin Lindblad-Toh; Jennifer Meadows; Matthew Webster; Alison Meynert; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Disease genetics; Ankylosing spondylitis; HLA typing; Imputation; Inference; Sex-stratified; HLA-B*27 independent; Association tests; Functional validation; Bioinformatics; Bioinformatik; Molekylär genetik; Molecular Genetics;

    Sammanfattning : The human leukocyte antigen (HLA) plays a major role in keeping us healthy, but some of the HLA alleles can contribute to disease susceptibility. One example is HLA-B*27, which confers increased susceptibility of ankylosing spondylitis and represents one of the strongest genetic associations found in any common human disease. LÄS MER

  3. 2. Image-based multi-omics data integration : Exploring whole-body PET/MRI, -omics data and body composition

    Författare :Robin Visvanathar; Håkan Ahlström; Joel Kullberg; Jan Eriksson; Katrine Riklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Body composition; Imiomics; genomics; metabolomics; MRI; PET; insulin sensitivity; T2D;

    Sammanfattning : Advanced body composition analysis with whole-body imaging could uncover novel associations between regional tissue composition and metabolic disease. Imiomics is an automated image analysis framework that enables large-scale integration of magnetic resonance imaging (MRI) data and orthogonal technologies such as metabolomics and genomics for the detailed study of body composition. LÄS MER

  4. 3. Complex disease genetics : Utilising targeted sequencing and homogeneous ancestry

    Författare :Argyri Mathioudaki; Kerstin Lindblad-Toh; Panagiotis Deloukas; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ankylosing spondylitis; breast cancer; targeted sequencing; Sweden; genetics; population stratification.; Molekylär genetik; Molecular Genetics;

    Sammanfattning : The complex disease investigations presented in this thesis aimed to provide new information regarding underlying genetics by using targeted sequencing and ethnically homogeneous cohorts. This work moved past current methodologies and addressed data stratification issues, that might have been hindering new findings. LÄS MER

  5. 4. Predictors and consequences of injurious falls among older adults : a holistic approach

    Författare :Stina Ek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The field of research on falls among older adults is well studied. Despite this, there are some knowledge gaps that need to be addressed: 1) research studying injurious falls, as opposed to any falls; 2) knowledge on sex differences, and specific risk profiles for injurious falls; 3) development of an effective screening tool for community-dwelling older adults, that can detect people at risk of first-time falls, who may be targeted by preventive interventions; and 4) what factors influence the risk of losing independence, in a long-term perspective, after an injurious fall. LÄS MER

  7. 5. Epidemiological studies of Helicobacter pylori and its relation to cancer and precancerous lesions in the upper gastrointestinal tract

    Författare :Maria Held; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Helicobacter pylori; atrophic gastritis; gastric cancer; esophagus cancer;

    Sammanfattning : Helicobacter pylori infection is strongly associated with gastric cancer risk. The carcinogenic process is supposed to occur step by step, from a normal gastric epithelium via gastritis, atrophy, intestinal metaplasia to dysplasia. LÄS MER