Sökning: "Serge Muyldermans"

Hittade 2 avhandlingar innehållade orden Serge Muyldermans.

  1. 1. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting

    Författare :Camilla Hofström; Torbjörn Gräslund; Serge Muyldermans; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecules; affinity proteins; radionuclide molecular imaging; intracellular targeting; EGFR; HER2; IGF-1R; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Sammanfattning : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. LÄS MER

  3. 2. Engineering of alternative scaffold derived drug conjugates and fusion-toxins for targeted cancer therapy

    Författare :Wen Yin; Torbjörn Gräslund; Serge Muyldermans; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HER2; Affibody; Cancer; ADAPT; Protein engineering; PE38; DM1; MMAE; MMAF; Biotechnology; Bioteknologi;

    Sammanfattning : Cancer is a major health problem, with premature death for many patients, and with a high monetary cost to society. The disease is complex to treat due to the many different types, but also because the disease-causing cells, that needs to be removed, are very similar to the normal cells. LÄS MER