Sökning: "SPIONs"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet SPIONs.

  1. 1. Superparamagnetic iron oxide nanoparticles (SPIONs) as a multimodality imaging probe for sentinel nodes : Design and Preclinical Evaluation

    Författare :Renata Madru; Lund Medicinsk strålningsfysik; []
    Nyckelord :iron oxide; nanoparticles; SPIONs; PET-MRI; SPECT-MRI; SPECT-MRI- optical imaging; sentinel lymph node; SNL;

    Sammanfattning : Breast cancer and malignant melanoma disseminate through the lymphatic system and the first metastases arise in one or two regional, sentinel lymph nodes (SLNs) draining the primary tumour site. Therefore, identification and characterization of the SLNs is of major importance for cancer staging and for choice of therapy in patients. LÄS MER

  3. 2. Engineered core : shell nanoparticles: synthesis, characterisation, and biocompatibility studies

    Författare :Carmen Mihaela Vogt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as promising contrast agents for Magnetic Resonance Imaging (MRI). Some SPIONs are already approved for clinical use. Coating of these nanoparticles with an additional biocompatible layer serves to improve the colloidal stability and biocompatibility. LÄS MER

  4. 3. Environment-Sensitive Multifunctional Drug Delivery Systems

    Författare :Jian Qin; Mamoun Muhammed; Marcus Textor; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Materials chemistry; Materialkemi;

    Sammanfattning : Drug delivery systems (DDS) with multiple functionalities such as environment-sensitive drug release mechanisms and visualization agents have motivated the biomedical community as well as materials chemists for more than a decade. This dissertation is concerned with the development of nanoparticles for multifunctional DDS  to tackle several crucial challenges in these complex systems, including polymeric nanospheres which respond to temperature change, superparamagnetic iron oxide nanoparticles/polymeric composite for magnetic resonance imaging contrast agents and drug carriers, immunoresponse of nanomaterials and injectable magnetic field sensitive ferrogels. LÄS MER

  5. 4. Applications of nanotechnology in neuroscience : functionalized superparamagnetic nanoparticles as contrast enhancers in experimental magnetic resonance imaging

    Författare :Fu-Hua Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Magnetic resonance imaging (MRI) is a noninvasive imaging technique that helps clinicians not only to diagnose but also to plan the treatment of invasive surgery and actually treat medical conditions. Superparamagnetic iron oxide nanoparticles (SPIONs) are a family of MRI contrast agents that improves MRI sensitivity/specificity. LÄS MER

  7. 5. Ultrasound Contrast Agents Loaded with Magnetic Nanoparticles : Acoustic and Mechanical Characterization

    Författare :VeeraVenkata Satyanarayana Kothapalli; Lars-Åke Brodin; Jan Engvall; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Ultrasound contrast agents; SPION nanoparticles; harmonic oscillation; backscattering power; attenuation coefficient; phase velocity; nonlinear equation of motion;

    Sammanfattning : The current methodologies in body scanning diagnostic uses different simultaneous imaging modalities like Ultrasound (US), magnetic resonance imaging (MRI), single photon emission tomography (SPECT) and positron emission tomography (PET). The field requires combination of different modalities for effective use in clinical diagnostics. LÄS MER