Sökning: "Reactive oxidant species"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden Reactive oxidant species.

  1. 1. Oxidant-induced cell death in lymphocytes: mechanisms of induction and resistance

    Författare :Fredrik Bergh Thorén; Göteborgs universitet; []
    Nyckelord :reactive oxygen species; cell death; apoptosis; poly ADP-ribose polymerase-1; apoptosis-inducing factor; natural killer cells; phagocytes; dendritic cells;

    Sammanfattning : Reactive oxygen species (oxidants, oxygen radicals) produced by the phagocytic NADPH oxidase have pivotal roles in immunity. Patients lacking a functional NADPH oxidase suffer from chronic granulomatous disease, which is characterized by recurring bacterial infections and thus manifesting the importance of reactive oxygen species in host defense against bacteria. LÄS MER

  3. 2. Functional genetic studies of Psoriasin: a potential biomarker for breast cancer with a poor prognosis

    Författare :Stina Petersson; Göteborgs universitet; []
    Nyckelord :Psoriasin; Breast cancer; Reactive oxidant species; NF-κB; IFNγ; STAT1; ICAM-1; MUC1; CD24;

    Sammanfattning : Breast cancer is the most common malignancy in women. There is a high degree of heterogeneity in breast tumours and they can be divided into subtypes that have different expression pattern and clinical outcome. Ductal Carcinoma in situ (DCIS) is regarded as a precursor of invasive ductal breast cancer. LÄS MER

  4. 3. Adipose tissue mitchondrial function is modulated by antioxidants

    Författare :Eduard Peris Franquet; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocyte; metabolism; browning; antioxidant; mitochondria; oxidative stress; adrenergic recpetor; N-acetylcysteine; glutathione; reactive oxygen species;

    Sammanfattning : Antioxidants are widely used as reactive oxygen species (ROS) scavenging agents in experimental research and in conditions where oxidative stress plays a primary role. However, the effect of antioxidant supplementation on white and brown adipose tissue functionality is understudied, and the role of ROS and/or antioxidant treatment during adipose tissue browning, a process in which the adipocytes’ mitochondrial density and activity increase, is largely unknown. LÄS MER

  5. 4. Mechanisms and mediators of apoptosis : with special reference to hematological disorders

    Författare :Bengt Fadeel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :apoptosis; Bcl-2; caspases; chemotherapy; chronic granulomatous disease; familial hemophagocytic lymphohistiocytosis; Fas; homology-based modeling; neutrophils; phosphatidylserine; reactive oxygen species;

    Sammanfattning : Life and death are inextricably entwined. Naturally occurring cell death or apoptosis is essential for the of homeostasis and serves to remove extraneous or dangerous cells in a swift and unobtrusive manner. work has demonstrated that such cell death is genetically regulated and transpires according to evolutionarily conserved pathways. LÄS MER

  7. 5. A model of pH and redox buffer depletion in waste landfills

    Författare :James Crawford; KTH; []
    Nyckelord :;

    Sammanfattning : The geochemical processes governing the release of heavymetal contaminants from solid waste materials have been studiedexperimentally and modelled using a mass balance approach. Theaim of the modelling work was to develop calculation tools thatcan be used to predict the release rate of heavy metals fromwaste heaps or landfills. LÄS MER