Sökning: "Protein-ligand binding interactions"

Visar resultat 11 - 15 av 26 avhandlingar innehållade orden Protein-ligand binding interactions.

1. 11. Structure and energetics of molecular recognition in galectin-3-ligand interactions

   Författare :Rohit Kumar; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein-ligand interactions; molecular recognition; weak bonds; thermodynamics; enthalpy; entropy; galectin-3; carbohydrate recognition domain; x-ray crystallography; fluorescence polarization; isothermal titration calorimetry; neutron crystallography; ;

   Sammanfattning : Molecular recognition is the key aspect of any cellular and biological function. Two or more molecules interacting with each other cause the effects that drives various basic functions that are fundamental to cells. Be these protein-protein, protein-nucleic acid or protein-ligand interactions, they all play important roles in a cell. LÄS MER

3. 12. Unlocking protein sequences : Advances in protein structure and ligand-binding site prediction

   Författare :Aditi Shenoy; Arne Elofsson; Geoffrey J Barton; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

   Sammanfattning : The protein sequence determines how it will fold into its unique three-dimensional structure. Once folded, proteins perform their functions by interacting with other proteins or molecules called ligands within the cell. Experimental determination of protein structure and function is tedious. LÄS MER

4. 13. Molecular recognition and dynamics in proteins studied by NMR

   Författare :Johan Wallerstein; Biofysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Chemical exchange; Conformational entropy; Entropy; Galectin-3; Isothermal Titration Calorimetry; ITC; Model-free formalism; Molecular recognition; Nuclear Magnetic Resonance; NMR; PGB1; Protein dynamics; Protein–ligand interactions; Proton-transfer reactions; Spin relaxation; Viscosity; Chemical exchange; Conformational entropy; Entropy; Galectin-3; Isothermal Titration Calorimetry; ITC; Model-free formalism; Molecular recognition; Nuclear Magnetic Resonance; NMR; PGB1; Protein dynamics; Protein–ligand interactions; Proton-transfer reactions; Spin relaxation; Viscosity;

   Sammanfattning : Knowledge of dynamics in protein is very important in the description of protein function and molecular recognition. The thesis investigates protein dynamics on time-scales from milli- to sub-nanosecond, with focus on the latter, using NMR spin relaxation experiments on two proteins, the 138-residue carbohydrate recognition domain of galectin-3 (Gal3C) and the 56-residue B1 domain of bacterial protein G (PGB1). LÄS MER

5. 14. Exploring Ligand Binding in HIV-1 Protease and K+ Channels Using Computational Methods

   Författare :Fredrik Österberg; Johan Åqvist; Olle Edholm; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; hERG; KcsA; AutoDock; LIE; molecular dynamics; ion channels; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : Understanding protein-ligand interactions is highly important in drug development. In the present work the objective is to comprehend the link between structure and function using molecular modelling. LÄS MER

7. 15. Functional analysis of ligand recognition by the glucocorticoid receptor

   Författare :Ulrika Lind; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :glucocorticoid receptor; steroid-binding; site-directed mutagenesis; protein-ligand interaction; mechanism of glucocorticoid action;

   Sammanfattning : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the superfamily of nuclear hormone receptors. It contains three structural and functional domains. LÄS MER