Sökning: "homology detection"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden homology detection.

  1. 1. Protein structure prediction : Zinc-binding sites, one-dimensional structure and remote homology

    Författare :Nanjiang Shu; Sven Hovmöller; Bruce Donald; Geoff Barton; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; zinc-binding; profile; homology detection; shape string; Bioinformatics; Bioinformatik; Molecular biology; Molekylärbiologi; Biochemistry; Biokemi; Structural Chemistry; strukturkemi;

    Sammanfattning : Predicting the three-dimensional (3D) structure of proteins is a central problem in biology. These computationally predicted 3D protein structures have been successfully applied in many fields of biomedicine, e.g. family assignments and drug discovery. LÄS MER

  3. 2. Sequence-based predictions of membrane-protein topology, homology and insertion

    Författare :Andreas Bernsel; Gunnar von Heijne; Volkhard Helms; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein; topology prediction; hidden markov model; homology detection; Sec translocon; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

    Sammanfattning : Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide variety of biochemical pathways. Apart from their general biological significance, membrane proteins are of particular interest to the pharmaceutical industry, being targets for more than half of all available drugs. LÄS MER

  4. 3. Hidden Markov models for remote protein homology detection

    Författare :Markus Wistrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Protein classification; hidden Markov model; homology detection; G proteincoupled receptor;

    Sammanfattning : Genome sequencing projects are advancing at a staggering pace and are daily producing large amounts of sequence data. However, the experimental characterization of the encoded genes and proteins is lagging far behind. LÄS MER

  5. 4. Detection and characterization of novel proteins in Trypanosoma cruzi

    Författare :Marcela Ferella; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Trypanosoma cruzi is a flagellated protozoan parasite. It infects a wide range of mammals, including humans. Human T. cruzi infections are endemic to South and Central America. LÄS MER

  7. 5. Interaction engineered three-helix bundle domains for protein recovery and detection

    Författare :Tove Alm; Sophia Hober; Rainer Hahn; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; ABD; Zbasic; albumin; protein engineering; phage display; staphylococcal display; inclusion bodies; refolding; proteomics; orthogonal affinity purification; Bioengineering; Bioteknik; Immunology engineering; Immunteknik;

    Sammanfattning : HTML clipboard The great advances in DNA technology, e.g. sequencing and recombinant DNA techniques, have given us the genetic information and the tools needed to effectively produce recombinant proteins. Recombinant proteins are valuable means in biotechnological applications and are also emerging as alternatives in therapeutic applications. LÄS MER