Sökning: "Ouabain resistance gene"

Hittade 3 avhandlingar innehållade orden Ouabain resistance gene.

1. 1. Vector development for suicide gene therapy

   Författare :Alar Aints; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Suicide gene therapy; VP22; selection markers; Ouabain resistance gene; GvHD; retroviral gene transfer;

   Sammanfattning : Gene therapy is used to treat conditions that arise from errors in the genetic makeup of cells either congenital diseases resulting from a deletion or mutation in a gene or malignant diseases where genetic regulation mechanisms have been deranged. Suicide gene therapy is one of several gene therapeutic approaches to treat cancer. LÄS MER

3. 2. Optimization of suicide gene therapy in stem cell transplantation with special reference to the selection marker OuaSelect

   Författare :Alexandra Treschow; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Gene therapy; cell selection; suicide gene; cancer; immunotherapy; viral vectors; thymidine kinase; Na ; K -ATPase;

   Sammanfattning : For many patients suffering from leukemia and other hematological malignancies, allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative approach. However, an optimal HSCT procedure is yet to be developed. Transplant-related morbidity and mortality are severe complications arising from this treatment modality. LÄS MER

4. 3. Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures

   Författare :Lubna Al-Khalili; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Skeletal muscle cultures; insulin signal transduction; glucose transport; GLUT4; RNAi; Na ; K -ATPase; MEF2;

   Sammanfattning : Skeletal muscle is an insulin sensitive organ and plays a major role in whole body electrolyte and substrate homeostasis in the post prandial state. Impaired insulin action in skeletal muscle may lead to the pathological condition of insulin resistance. LÄS MER