Sökning: "Molt"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Molt.

  1. 1. On New Implants - The results of five prospective, randomized RSA trials with aspects on phased introduction and continuous migration

    Författare :Mats Molt; Lund Ortopedi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; New total knee arthroplasty; TKA; RSA; randomized; prospective; prediction; continuously migrating; safety; stability CR; PS; PF; PA; short stem; tourniquet;

    Sammanfattning : A concern that arises with any change in design or operative technique is whether it affects the long-term implant stability or not. One way to address this is, by measuring early micromotion, to predict the future revision rate. LÄS MER

  3. 2. Optimizing experimental radioimmunotherapy : investigating the different mechanisms behind radiation induced cell deaths

    Författare :Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

    Sammanfattning : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. LÄS MER

  4. 3. Studies on anti-leukemic terpenoids from medicinal mushrooms and marine sponges with ChemGPS-NP-based targets investigation of lead compounds

    Författare :Kuei-Hung Lai; Anders Backlund; Christina Wedén; Fang-Rong Chang; Yang-Chang Wu; Nicholas Oberlies; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChemGPS-NP analysis; antileukemic agents; lanostanoids; sesterterpenoids; manoalide; Pharmacognosy; Farmakognosi;

    Sammanfattning : This thesis investigates the anti-leukemic activity of terpenoids isolated from medicinal mushrooms and marine sponges, as well as their possible targets and mechanisms of action.In the first section, we focused on studying the triterpenoidal components of three triterpenoid-enriched medicinal mushrooms Antrodia cinnamomea, Ganoderma lucidum, and Poria cocos, which have been used in folk medicine for centuries and also developed into several contemporary marketed products. LÄS MER

  5. 4. Pharmacology and resistance mechanisms of nucleoside analogues and topoisomerase II interactive agents : studies on human leukemia cells with a focus on cross-resistance

    Författare :Kourosh Lotfi; Rolf Larsson; Linköpings universitet; []
    Nyckelord :Nucleoside analogue; cross-resistance; multidrug resistance; deoxycytidine kinase; leukemia; anthracyclines; P-glycoprotein; MEDICINE; MEDICIN;

    Sammanfattning : The purpose of this thesis was to elucidate mechanisms of action and resistance of clinically relevant nucleoside analogues and topoisomerase interactive agents in human leukemia cell lines and leukernia cells isolated from peripheral blood of leukemia patients. Interactions and cross-resistance patterns of these different cytotoxic drug families were also studied since these drugs are usually administrated in combination in the clinic. LÄS MER

  7. 5. Human herpesvirus 6A and 6B : assay validation, virus-host interaction and clinical relevance

    Författare :Elin Engdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human herpesvirus (HHV)-6A and HHV-6B are two ubiquitous herpesviruses that after primary infection can stay latent in the host. The two viruses can reactivate from latency and cause secondary complications. Also, diseases like multiple sclerosis and epilepsy have been associated with HHV-6A and HHV-6B. LÄS MER