Sökning: "Lewis blood group"

Visar resultat 6 - 10 av 20 avhandlingar innehållade orden Lewis blood group.

  1. 6. Studies on the biosynthesis of ABH and Lewis epitopes on O-glycans

    Författare :Jonas Löfling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fucose; Lewis antigen; Blood group ABH; biosynthesis;

    Sammanfattning : ABH and Lewis antigens are carbohydrate epitopes (glycans) found on a wide variety of cell surfaces. They are involved in many biological processes, e.g transplantation rejection, bacterial and viral adhesion, cell-cell communication and metastasis. The in vivo synthesis of glycans is mediated by glycosyltransferases (GTs). LÄS MER

  3. 7. Synthesis of biologically active oligosaccharides of the Lewis b family and investigations towards the synthesis of glycoclusters

    Författare :Linnéa Skantz; Martina Lahmann; Thisbe Lindhorst; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Lewis b; lactosamine; dendrimers; oxazolidinone; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Sammanfattning : The gastric pathogen Helicobacter pylori is a Gram negative bacterium which may cause diseases such as peptic ulceration and gastric adenocarcinoma. It colonises a host by attaching to the gastric epithelial cells, an attachment mediated by outer membrane proteins on the bacterial surface, e.g, the blood group antigen binding adhesin, BabA. LÄS MER

  4. 8. Adaptation of Helicobacter pylori Adherence Properties in Promotion of Host Tropism and Inflammatory Disease

    Författare :Marina Aspholm; Rino Rappuoli; Umeå universitet; []
    Nyckelord :H. pylori; BabA; SabA; adhesin; blood group antigens; sialylated; phase variation; hemagglutination; selectin; adaptation; odontologi; Odontology;

    Sammanfattning : Being among the most prevalent of persistent infectious agents in humans worldwide, Helicobacter pylori induces chronic inflammation (gastritis), which may progress to peptic ulceration and stomach cancer. The ability to adhere to the gastric mucosa is considered to be both a colonization and virulence property of H. pylori. For adherence, H. LÄS MER

  5. 9. Evaluation of fucosylated receptors for Cholera toxin in the human small intestine

    Författare :Jakob Cervin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholera toxin; Lewis antigen; HBGA; HMO; Fucose; GM1;

    Sammanfattning : Cholera toxin (CT) produced by Vibrio cholerae is the causative agent for the diarrheal disease cholera. Cholera is yearly afflicting millions and is estimated to kill over 100 000 people every year. In this thesis I aimed to better understand the role of noncanonical CT receptors, e.g. LÄS MER

  7. 10. Gastrointestinal norovirus infections and the development of the next generation of mucosal vaccines

    Författare :Inga Rimkute; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human norovirus; gastrointestinal infection; mucosal vaccine; subcomponent vaccine; human intestinal enteroids; histo-blood group antigens; lipidomics; glycoproteomics; glycosphingolipids;

    Sammanfattning : Human norovirus (HuNoV) is the causative agent of the winter vomiting disease and the leading cause of outbreaks of gastrointestinal infections across all settings and age groups in the world. The virus is highly contagious making outbreaks difficult or often impossible to control and having a high impact on societal costs and resources. LÄS MER