Sökning: "L-DOPA"

Visar resultat 6 - 10 av 75 avhandlingar innehållade ordet L-DOPA.

  1. 6. Emerging pharmacotherapies for Parkinson's Disease: Experimental studies in the rat

    Författare :Hanna Iderberg; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s Disease; L-DOPA; L-DOPA-induced dyskinesia; rat model of Parkinson s disease; behavioural pharmacology;

    Sammanfattning : Parkinson´s disease (PD) is a neurodegenerative disorder characterized by the typical motor symptoms, akinesia/bradykinesia, rigidity and resting tremor. These symptoms are caused by a deficiency of dopamine (DA) in the brain, which depends on degeneration of DA neurons in the substantia nigra. LÄS MER

  3. 7. Striatal adaptations in experimental parkinsonism and L-DOPA-induced dyskinesia

    Författare :Tim Fieblinger; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatum; Parkinson’s disease; L-DOPA-induced dyskinesia; ERK1 2; mGluR5; homeostatic plasticity; SPN; 2‑Photon microscopy;

    Sammanfattning : Parkinson’s disease (PD) is a neurodegenerative disorder, characterized by the loss of dopamine (DA) producing neurons in the substantia nigra pars compacta (SNc), resulting in typical motor symptoms. DA replacement with L-DOPA is the standard therapy for PD. LÄS MER

  4. 8. Transcriptional dysregulation in L-DOPA-induced dyskinesia

    Författare :Malin Andersson; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; neurofysiologi; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; CREB; jun; fos; immediate early genes; prodynorphin; striatal plasticity; Parkinson s disease; dyskinesia; Klinisk genetik;

    Sammanfattning : This study explores the role of transcriptional regulation important in the development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. In patients with Parkinson’s disease, dyskinesia is one of the most difficult complications of the DA-replacement therapy by L-DOPA. LÄS MER

  5. 9. Presynaptic mechanisms in L-DOPA-induced dyskinesia

    Författare :Hanna Lindgren; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; dyskinesia; 5-HT; DA; Parkinson s disease; 6-OHDA; microdialysis;

    Sammanfattning : This study has investigated the impact of presynaptic factors on the development of dyskinesia during chronic L-DOPA treatment in a rat model of Parkinson’s disease (PD). The mechanisms causing dyskinesia are not completely understood but have been proposed to involve changes in gene and protein expression in striatal neurons, which are the main target of dopamine (DA) projections from the substantia nigra pars compacta (SNpc). LÄS MER

  7. 10. Imaging neurochemical changes associated with Parkinson´s disease and L-DOPA-induced dyskinesia using mass spectrometry

    Författare :Elva Fridjonsdottir; Per E. Andrén; Miles Trupp; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; MALDI; Parkinson´s disease; L-DOPA-induced dyskinesia;

    Sammanfattning : Parkinson’s disease (PD), caused by a loss of midbrain dopamine neurons, is the second most common neurodegenerative disease worldwide after Alzheimer’s disease. The primary treatment choice for PD is L-DOPA, the precursor for dopamine, which only affects symptoms and does not inhibit disease progression. LÄS MER