Sökning: "JAK STAT"

Visar resultat 11 - 15 av 41 avhandlingar innehållade orden JAK STAT.

  1. 11. Growth hormone, JAKs and STATs : a model cytokine signal transduction system

    Författare :Tim Wood; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The haematopoietic cytokine family of signalling molecules comprises a variety of polypeptides which have pleiotropic effects on cell differentiation, tissue development and homeostasis. The family includes several interleukins, a variety of growth and colony stimulating factors, erythropoietin, leukaemia inhibitory factor, ciliary neurotrophic factor, the interferons, as well as leptin, prolactin and growth hormone. LÄS MER

  3. 12. Regulation of STAT5 activity by growth hormone

    Författare :Tony J Pircher; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :growth hormone janus kinase; STAT5; MAP kinase; phosphatase;

    Sammanfattning : The growth hormone (GH) receptor is a member of the cytokine receptor superfamily. This receptor family has certain common characteristics, among them the absence of a canonical tyrosine kinase consensus sequence and the association with the Janus family of cytosolic tyrosine kinases (JAK). The predominant JAK utilized by the GH receptor is JAK2. LÄS MER

  4. 13. Gene regulation in psoriatic keratinocytes : microRNAs and cytokine responses

    Författare :Ankit Srivastava; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Psoriasis is the most common chronic skin inflammation in adults which affects 2-4% of the world population. Keratinocytes are the key structural cells in epidermis which hyper-proliferate and undergo aberrant differentiation in psoriasis. LÄS MER

  5. 14. On the pro-apoptotic signaling induced by interferon-alpha

    Författare :Linn Hjortsberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Interferon-alpha (IFNalpha) is a pleiotropic cytokine which has been used as an active drug in the treatment of malignant diseases for almost five decades. It has shown beneficial results in several hematological malignancies, as well as solid tumors, including hairy cell leukemia, multiple myeloma, chronic myeloid leukemia, renal carcinoma and malignant melanoma. LÄS MER

  7. 15. Leptin targets in the brain regulating body weight : receptors and down-stream mediators of leptin in neurons of the hypothalamus and brainstem

    Författare :Marie-Louise Håkansson Ovesjö; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AGRP; antibody; arcuate nucleus; blood-brain-barrier; body weight; brainstem; CART; CRH; DMX; food intake; GABA; GAD; galanin; hypothalamus; immunohistochemistry; in situ hybridization; lateral hypothalamic area; leptin; leptin receptor; MCH; NPY; obesity; Ob-R; Ob-Rb; oxytocin; paraventricular nucleus; POMC; somatostatin; serotonin; STAT3; supraoptic nucleus; transcription factor; vasopressin; VGAT;

    Sammanfattning : Obesity is a disease which has become a global epidemic that is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health in the world. In particular, obesity is associated with diabetes mellitus, hypertension and coronary heart disease. LÄS MER