Sökning: "Integron"
Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet Integron.
1. Mechanisms and DNA Specificity in Site-specific Recombination of Integron Cassettes
Sammanfattning : Bacterial resistance to antibiotics has become a serious problem. This is due to the remarkable ability of bacteria to respond and rapidly adapt to environmental changes. Integrons are elements with the capacity for gene capture by an integron-encoded site-specific recombinase called IntI. LÄS MER
2. Identification of novel antibiotic resistance genes through the exploration of mobile genetic elements
Sammanfattning : Backgrounds and aims: The evolution of multi-resistant pathogens is seriously threatening our ability to provide modern healthcare. Many of the mobile resistance factors in clinics appear to originate from environmental bacteria. LÄS MER
3. Computational Modelling of Ligand Complexes with G-Protein Coupled Receptors, Ion Channels and Enzymes
Sammanfattning : Accurate predictions of binding free energies from computer simulations are an invaluable resource for understanding biochemical processes and drug action. The primary aim of the work described in the thesis was to predict and understand ligand binding to several proteins of major pharmaceutical importance using computational methods. LÄS MER
4. Mechanisms and DNA-specificity in site-specific recombination of integron cassettes
Sammanfattning : .... LÄS MER
5. Statistical modelling and analyses of DNA sequence data with applications to metagenomics
Sammanfattning : Microorganisms are organised in complex communities and are ubiquitous in all ecosystems, including natural environments and inside the human gut. Metagenomics, which is the direct sequencing of DNA from a sample, enables studying the collective genomes of the organisms that are there present. LÄS MER