Sökning: "site-specific recombination"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden site-specific recombination.

  1. 1. Site-Specific Recombination : Integrases, Accessory Factors and DNA Targets of P2-like Coliphages

    Författare :Lina Sylwan; Elisabeth Haggård-Ljungquist; Margaret C. M. Smith; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The temperate coliphage P2 and its family members integrate their genomes into the host Escherichia coli chromosome by a site-specific recombination mechanism to form lysogeny. Integration takes place between the complex phage attP site and the simple bacterial attB site and is catalyzed by the phage encoded integrase (Int). LÄS MER

  3. 2. Mechanisms and DNA Specificity in Site-specific Recombination of Integron Cassettes

    Författare :Carolina Johansson; Lars Sundström; Dan Andersson; Didier Mazel; Uppsala universitet; []
    Nyckelord :Microbiology; lateral gene transfer; site-specific recombination; tyrosine recombinase; integron; single-stranded; DNA hairpin; Mikrobiologi; farmaceutisk mikrobiologi; Pharmaceutical Microbiology;

    Sammanfattning : Bacterial resistance to antibiotics has become a serious problem. This is due to the remarkable ability of bacteria to respond and rapidly adapt to environmental changes. Integrons are elements with the capacity for gene capture by an integron-encoded site-specific recombinase called IntI. LÄS MER

  4. 3. Site-specific recombination of P2-like phages; possible tools for safe gene therapy : A focus on phage ΦD145

    Författare :Sridhar Mandali; Elisabeth Haggård-Ljungquist; Richard Calendar; Stockholms universitet; []
    Nyckelord :bacteriophage; integrase; site-specific recombination; NATURAL SCIENCES; NATURVETENSKAP; molekylärgenetik; Molecular Genetics;

    Sammanfattning : P2-like bacteriophages integrate their genome into the E. coli host cell by a site-specific recombination event upon lysogenization. The integrative recombination occurs between a specific sequence in the phage genome, attP, and a specific sequence in the host genome, attB, generating the host-phage junctions attL and attR. LÄS MER

  5. 4. Site-specific recombination in P2-like coliphages

    Författare :Carlos Cardoso Palacios; Elisabeth Haggård-Ljungquist; Didier Mazel; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The scope of these studies has been to investigate the site-specific recombination systems of P2-like coliphages, both in an evolutionary perspective by a comparative analysis of related phages as well as in a functional perspective. Surveys of P2-like phages in Escherichia coli isolated from nature reveal the existence of seven discrete immunity classes and three integration sites, one of them previously unknown. LÄS MER

  7. 5. Mechanisms and DNA-specificity in site-specific recombination of integron cassettes

    Författare :Carolina Johansson; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER