Sökning: "Harald Kolmar"

Hittade 4 avhandlingar innehållade orden Harald Kolmar.

1. 1. Combinatorial Protein Engineering Of Affibody Molecules Using E. Coli Display And Rational Design Of Affibody-Based Tracers For Medical Imaging

   Författare :Ken G. Andersson; John Löfblom; Stefan Ståhl; Harald Kolmar; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; directed evolution; microbial display; E. coli; Affibody molecule; autotransporter; medical imaging; HER receptor family; Sortase A; Bioteknologi; Biotechnology;

   Sammanfattning : Directed evolution is today an established strategy for generation of new affinity proteins. This thesis describes the development of a cell-display method using Escherichia coli for directed evolution of Affibody molecules. LÄS MER

3. 2. Targeting HER2-expressing tumors with potent drug conjugates and fusion toxins based on scaffold proteins

   Författare :Haozhong Ding; Torbjörn Gräslund; Stefan Ståhl; Harald Kolmar; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Targeted therapy; affibody molecules; ADAPT molecules; AffiDC; fusion toxins; HER2; Biotechnology; Bioteknologi;

   Sammanfattning : Targeted therapy is an emerging treatment for a variety of cancers. Small- sized scaffold proteins are an alternative to conventional antibody-based targeting molecules. LÄS MER

4. 3. Chemical Synthesis of Affibody Molecules for Protein Detection and Molecular Imaging

   Författare :Torun Ekblad; Amelie Eriksson Karlström; Per-Åke Nygren; Harald Kolmar; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; peptide synthesis; protein detection; molecular imaging; Bioengineering; Bioteknik;

   Sammanfattning : Proteins are essential components in most processes in living organisms. The detection and quantification of specific proteins can be used e.g. as measures of certain physiological conditions, and are therefore of great importance. LÄS MER

5. 4. Bacterial display systems for engineering of affinity proteins

   Författare :Filippa Fleetwood; John Löfblom; Harald Kolmar; KTH; []
   Nyckelord :Combinatorial protein engineering; staphylococcal display; Affibody; biparatopic; VEGFR2; nanobody; E. coli display; autotransporter; Bioteknologi; Biotechnology;

   Sammanfattning : Directed evolution is a powerful method for engineering of specific affinity proteins such as antibodies and alternative scaffold proteins. For selections from combinatorial protein libraries, robust and high-throughput selection platforms are needed. LÄS MER