Sökning: "H3K27me3"
Visar resultat 1 - 5 av 28 avhandlingar innehållade ordet H3K27me3.
1. Genetic and Epigenetic Characterisation of Breast Tumours
Sammanfattning : Breast tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. LÄS MER
2. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation
Sammanfattning : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. LÄS MER
3. Epigenetic gene regulation in multiple myeloma and mood disorders
Sammanfattning : Epigenetics continues to be redefined and new discoveries are likely to revolutionise the field still further. This thesis explores different aspects of how epigenetic regulation of gene expression contributes to human disease. LÄS MER
4. Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma : Implications for Biology and Therapy
Sammanfattning : Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/plasma cells. MM is characterized by extensive genetic and clonal heterogeneity, which have hampered the attempts to identify a common underlying mechanism for disease establishment and development of appropriate treatment regimes. LÄS MER
5. Quantitative methods for profiling dynamic chromatin features
Sammanfattning : Living systems, from entire organisms down to the single cells constituting them are dynamic entities that continuously adapt and respond to their local environment. Cells achieve this through gene expression programs derived from static information encoded in the DNA made dynamic through chemical modifications at the chromatin level, collectively termed the epigenome. LÄS MER
